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Volume 26, Number 6—June 2020
CME ACTIVITY - Research

Statin Use and Influenza Vaccine Effectiveness in Persons ≥ 65 Years of Age, Taiwan

Lung-Wen Tsai1, Yung-Tai Chen1, Chia-Jen Shih, Shuo-Ming OuComments to Author , Pei-Wen Chao, and Shih-Hsiu LoComments to Author 
Author affiliations: Taipei Medical University Hospital, Taipei, Taiwan (L.-W. Tsai, P.-W. Chao, S.-H. Lo); Taipei City Hospital, Taipei (Y.-T. Chen); University of Taipei, Taipei (Y.-T, Chen); National Yang-Ming University, Taipei (Y.-T. Chen, C.-J. Shih, S.-M. Ou); Taipei Veterans General Hospital, Taipei (S.-M. Ou)

Main Article

Table 3

Comparison of statin users and nonusers >65 years of age for incidence and risk for hospitalization, pneumonia, circulatory conditions, critical illness, and death who are vaccinated and unvaccinated for influenza, Taiwan*

Characteristics Vaccinated
 Unvaccinated (referent)
 Hazard ratio (95% CI)†
No. Person-years Incidence‡ No. Person-years Incidence‡ Crude Adjusted
In-hospital death§ 38,320 2,984,344 12.84 55,405 2,949,054 18.79 0.68 (0.67–0.69) 0.69 (0.68–0.69)
Statin user 1,478 147,164 10.04 22,097 146,668 14.30 0.70 (0.66–0.75) 0.71 (0.67–0.76)
Statin nonuser
 36,842
 2,837,180
 12.99
53,308
 2,802,386
 19.02
0.68 (0.67–0.69)
 0.68 (0.68–0.69)
In-hospital death from pneumonia¶ 15,057 2,984,931 5.04 20,699 2,950,157 7.02 0.72 (0.70–0.73) 0.72 (0.70–0.73)
Statin user 503 147,202 3.42 665 146,723 4.53 0.75 (0.67–0.85) 0.75 (0.67–0.85)
Statin nonuser
 14,554
 2,837,730
 5.13
20,034
 2,803,435
 7.15
0.72 (0.70–0.73)
 0.72 (0.70–0.73)
Hospitalization for pneumonia or influenza# 103,395 2,946,802 35.09 121,776 2,907,115 41.89 0.84 (0.83–0.84) 0.84 (0.84–0.85)
Statin user 3,967 145,687 27.23 4,810 144,805 33.22 0.82 (0.79–0.86) 0.82 (0.79–0.86)
Statin nonuser
 99,428
 2,801,115
 35.50
116,966
 2,762,309
 42.34
0.84 (0.83–0.85)
 0.84 (0.84–0.85)
Hospitalization for circulatory condition** 394,245 2,801,412 140.73 430,954 2,750,954 156.66 0.90 (0.90–0.90) 0.90 (0.90–0.90)
Statin user 25,141 134,914 186.35 27,991 132,843 210.71 0.89 (0.87–0.90) 0.90 (0.88–0.91)
Statin nonuser
 369,104
 2,666,498
 138.42
402,963
 2,618,111
 153.91
0.90 (0.90–0.90)
 0.90 (0.89–0.90)
Hospitalization for critical illness†† 62,018 2,968,927 20.89 82,602 2,929,804 28.19 0.74 (0.73–0.75) 0.75 (0.74–0.76)
Statin user 2,614 146,432 17.85 3,574 145,677 24.53 0.73 (0.69–0.77) 0.74 (0.71–0.78)
Statin nonuser 59,404 2,822,496 21.05 79,028 2,784,127 28.39 0.74 (0.73–0.75) 0.75 (0.74–0.76)

*Values after propensity score-matching between persons who received and did not receive influenza vaccination.
†Calculated by Cox regression model with adjusted imbalance covariates listed in Table 1. In all cases, p<0.001.
‡Per 1,000 person-years.
§Interaction p = 0.478.
¶Interaction p = 0.493.
#Interaction p = 0.138.
**Interaction p = 0.667.
††Interaction p = 0.375.

Main Article

1These authors contributed equally to this study.

Page created: May 15, 2020
Page updated: May 15, 2020
Page reviewed: May 15, 2020
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