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Volume 27, Number 1—January 2021

Seventh Pandemic Vibrio cholerae O1 Sublineages, Central African Republic

Sebastien Breurec1, Thierry Franck12, Elisabeth Njamkepo, Jean-Robert Mbecko, Jean Rauzier, Hugues Sanke-Waïgana, Guyguy Kamwiziku, Renaud Piarroux, Marie-Laure Quilici3, and François-Xavier Weill3Comments to Author 
Author affiliations: Institut Pasteur de la Guadeloupe, Les Abymes, France (S. Breurec); INSERM Centre d’Investigation Clinique 1424, Pointe-à-Pitre/Les Abymes, France (S. Breurec); Université des Antilles, Pointe-à-Pitre, France (S. Breurec); Institut Pasteur de Bangui, Bangui, Central African Republic (S. Breurec, T. Franck, J.-R. Mbecko); Institut Pasteur, Paris, France (E. Njamkepo, J. Rauzier, M.-L. Quilici, F.-X. Weill); Université de Kinshasa, Kinshasa, Democratic Republic of the Congo (G. Kamwiziku); Assistance Publique-Hôpitaux de Paris, Paris (R. Piarroux)

Main Article

Table 1

Characteristics of the Vibrio cholerae O1 isolates associated with outbreaks of cholera, Central African Republic*

Outbreak no. 1, 1997 Jun–Oct
Outbreak no. 2, 1997 Jun–Aug
Outbreak no. 3, 2011 Sept–Oct
Outbreak no. 4, 2016 Jul–Dec
No. deaths/no. cases† 88/443 19/113 16/172 20/265
No. isolates 9 6 7 8
7PET sublineage T7 T9 T10 T10
Sequence type 69 69 515 515
ctxB B3 B1 B1 B1
wbeT A03 C19 B01 B01
AMR phenotypes (no. isolates)§
R1 (8), R2 (1)
R3 (6)
R3 (7)
R3 (8)
AMR determinants
Plasmid IncA/C¶ NT NT NT
VC_0715 WT R169C R169C R169C
VC_A0637 WT Q5Stop Q5Stop Q5Stop
SXT/R391 element NT ICEVchInd5 ICEVchInd5 ICEVchInd5
gyrA WT WT S83I S83I

*7PET, seventh pandemic Vibrio cholerae O1 El Tor; AMR, antimicrobial resistance; NT, not detected; WT, wild type.
†Data from the International Federation of Red Cross and Red Crescent Societies 2011 ( and 2016 (
‡Nomenclature according to Weill et al. (3) (Table 2).
§R1, resistance to polymyxin B and colistin; R2, resistance to polymyxin B, colistin, ampicillin, streptomycin, sulfonamides, vibriostatic agent, trimethoprim/sulfamethoxazole, chloramphenicol; R3, resistance to polymyxin B, colistin, streptomycin, sulfonamides, vibriostatic agent, trimethoprim/sulfamethoxazole, furazolidone, and resistance or intermediate resistance to chloramphenicol.
¶Isolate (CNRVC970079) with the R2 AMR type.

Main Article

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Main Article

1These first authors contributed equally to this article.


3These authors were joint principal investigators.

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