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Volume 27, Number 8—August 2021
Research

Estimates of Toxoplasmosis Incidence Based on Healthcare Claims Data, Germany, 2011–2016

Amrei KringsComments to Author , Josephine Jacob, Frank Seeber, Uwe Pleyer, Jochen Walker, Klaus Stark, and Hendrik Wilking
Author affiliations: Robert Koch Institute, Berlin, Germany (A. Krings, F. Seeber, K. Stark, H. Wilking); European Centre for Disease Prevention and Control, Stockholm, Sweden (A. Krings); InGef–Institute for Applied Health Research Berlin GmbH, Berlin (J. Jacob, J. Walker); Charité Universitätsmedizin Berlin, Berlin (U. Pleyer)

Main Article

Table 1

Case definitions for toxoplasmosis disease manifestations used in analysis of healthcare claims, Germany*

Toxoplasmosis manifestation Case definition
Non–pregnancy-associated
Ocular toxoplasmosis Patient with ICD-10 diagnosis code B58.0
Cerebral toxoplasmosis Patient with ICD-10 diagnosis code B58.2
Hepatitis through toxoplasmosis Patient with ICD-10 diagnosis code B58.1
Pneumonitis through toxoplasmosis Patient with ICD-10 diagnosis code B58.3
Toxoplasmosis of other specified sites
 Patient with ICD-10 diagnosis code B58.8
Unspecified toxoplasmosis
Patient with ICD-10 diagnosis code B58 or B58.9
Toxoplasmosis in mother and child
Congenital toxoplasmosis† Children <12 mo of age with ICD-10 code P37.1 or B58.9
Toxoplasmosis during pregnancy‡ Pregnant woman with ICD-10 code B58
AND 1 of the following laboratory tests: avidity testing (EBM 32640) or testing for Toxoplasma gondii in amniotic fluid or fetal blood (EBM 32833)
AND who received 1 of the following treatments: spiramycin (before 16th week of pregnancy), pyrimethamine in combination with sulfadiazine/clindamycin/atovaquone (after 16th week of pregnancy), trimethoprim/sulfamethoxazole

*The reference population for incidence estimation for each form of toxoplasmosis was all patients in the healthcare database not fulfilling the case definition. ICD-10, International Classification of Diseases, 10th Revision. †Reference population was children <1 year of age. ‡Reference population was female patients 15–50 y of age and pregnant. Pregnancy was defined based on ICD-10 diagnostic codes indicating birth, stillbirth, abortion, or miscarriage.

Main Article

Page created: June 16, 2021
Page updated: July 18, 2021
Page reviewed: July 18, 2021
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