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Volume 28, Number 1—January 2022

Transfusion-Transmitted Hepatitis A Virus, France, 2018

Caroline LefeuvreComments to Author , Caroline Lefort, Françoise Boyer, Sophie Le Cam, Lina Mouna, Anne-Marie Roque-Afonso, Hélène Le Guillou-Guillemette, and Rafaël Mahieu
Author affiliations: Angers University Hospital, Angers, France (C. Lefeuvre, F. Boyer, H. Le Guillou-Guillemette, R. Mahieu); University of Angers, Angers (C. Lefeuvre, H. Le Guillou-Guillemette, R. Mahieu); Etablissement Français du Sang Centre-Pays de la Loire, Angers (C. Lefort, S. Le Cam); University of Paris–Saclay, Villejuif, France (L. Mouna, A.-M. Roque-Afonso); French National Reference Center for Hepatitis A Virus, Villejuif (L. Mouna, A.-M. Roque-Afonso)

Main Article


Laboratory results from donor plasma and recipient serum in case of transfusion-transmitted HAV, France, 2018*

Source Sample date HAV test result (s/c)
HAV avidity index, %† HAV RNA, log10 IU/mL ALT, IU/L
Donor 2018 Jun 23 NR‡ NR§ ND <1.00 ND
Donor¶ 2018 Aug 28 NR‡ NR§ ND 5.43# ND
Recipient 2018 Jun 25 NR** NR†† ND ND 49
Recipient¶ 2018 Oct 25 R** (2.35) R†† (3.73) 12.95 5.82 3,553
Recipient 2018 Oct 30 ND ND ND ND 1,200
Recipient 2018 Nov 9 ND ND ND ND 144
Recipient 2018 Nov 19 ND ND 31.85 3.42 ND
Recipient 2018 Dec 10 ND ND 39.15 3.14 59
Recipient 2019 Jan 17 ND ND 44.00 <1.00 39

*ALT, alanine aminotransferase; HAV, hepatitis A virus; ND, test not done; NR, nonreactive; R, reactive; s/c, sample/cutoff ratio. †HAV avidity index was expressed as a percentage as follows: HAV avidity index = (the absorbance reading with urea wash/the absorbance reading without urea wash) × 100. Avidity index <50% indicates acute infection. ‡VIDAS Anti-HAV IgM (bioMérieux, Value >0.5 is considered reactive. §Elecsys Anti-HAV total antibodies (value >22 mIU/mL considered reactive) ¶Genotype IA was identified. #Result (log10 IU/mL) corresponds to HAV RNA quantification performed at the National Reference Center for HAV. The result of qualitative detection performed at the French National Blood Service was 3.27 (no unit). **ARCHITECT HAV Ab-IgM (Abbott Diagnostics, Value >1.20 is considered reactive. ††ARCHITECT HAV Ab-IgG (Abbott Diagnostics). Value >1.00 is considered reactive.

Main Article

Page created: November 30, 2021
Page updated: December 20, 2021
Page reviewed: December 20, 2021
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