Volume 28, Number 1—January 2022
Dispatch
Transfusion-Transmitted Hepatitis A Virus, France, 2018
, Caroline Lefort, Françoise Boyer, Sophie Le Cam, Lina Mouna, Anne-Marie Roque-Afonso, Hélène Le Guillou-Guillemette, and Rafaël Mahieu
Table
Laboratory results from donor plasma and recipient serum in case of transfusion-transmitted HAV, France, 2018*
| Source | Sample date | HAV test result (s/c) |
HAV avidity index, %† | HAV RNA, log10 IU/mL | ALT, IU/L | |
|---|---|---|---|---|---|---|
| IgM | IgG | |||||
| Donor | 2018 Jun 23 | NR‡ | NR§ | ND | <1.00 | ND |
| Donor¶ | 2018 Aug 28 | NR‡ | NR§ | ND | 5.43# | ND |
| Recipient | 2018 Jun 25 | NR** | NR†† | ND | ND | 49 |
| Recipient¶ | 2018 Oct 25 | R** (2.35) | R†† (3.73) | 12.95 | 5.82 | 3,553 |
| Recipient | 2018 Oct 30 | ND | ND | ND | ND | 1,200 |
| Recipient | 2018 Nov 9 | ND | ND | ND | ND | 144 |
| Recipient | 2018 Nov 19 | ND | ND | 31.85 | 3.42 | ND |
| Recipient | 2018 Dec 10 | ND | ND | 39.15 | 3.14 | 59 |
| Recipient | 2019 Jan 17 | ND | ND | 44.00 | <1.00 | 39 |
*ALT, alanine aminotransferase; HAV, hepatitis A virus; ND, test not done; NR, nonreactive; R, reactive; s/c, sample/cutoff ratio. †HAV avidity index was expressed as a percentage as follows: HAV avidity index = (the absorbance reading with urea wash/the absorbance reading without urea wash) × 100. Avidity index <50% indicates acute infection. ‡VIDAS Anti-HAV IgM (bioMérieux, https://www.biomerieux.com). Value >0.5 is considered reactive. §Elecsys Anti-HAV total antibodies (value >22 mIU/mL considered reactive) ¶Genotype IA was identified. #Result (log10 IU/mL) corresponds to HAV RNA quantification performed at the National Reference Center for HAV. The result of qualitative detection performed at the French National Blood Service was 3.27 (no unit). **ARCHITECT HAV Ab-IgM (Abbott Diagnostics, https://www.diagnostics.abbott). Value >1.20 is considered reactive. ††ARCHITECT HAV Ab-IgG (Abbott Diagnostics). Value >1.00 is considered reactive.