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Volume 28, Number 12—December 2022
Synopsis

Iceland as Stepping Stone for Spread of Highly Pathogenic Avian Influenza Virus between Europe and North America

Anne Günther1, Oliver Krone1, Vilhjalmur Svansson1, Anne Pohlmann, Jacqueline King, Gunnar Thor Hallgrimsson, Kristinn Haukur Skarphéðinsson, Heiða Sigurðardóttir, Stefán Ragnar Jónsson, Martin Beer, Brigitte Brugger, and Timm HarderComments to Author 
Author affiliations: Friedrich-Loeffler-Institute, Greifswald–Insel Riems, Germany (A. Günther, A. Pohlmann, J. King, M. Beer, T. Harder); Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany (O. Krone); University of Iceland, Reykjavik, Iceland (V. Svansson, G.T. Hallgrimsson, H. Sigurðardóttir, S.R. Jónsson); Icelandic Institute of Natural History, Garðabær, Iceland (K.H. Skarphéðinsson); Icelandic Food and Veterinary Authority, Selfoss, Iceland (B. Brugger)

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Figure 2

Phylogeographic tree of highly pathogenic avian influenza viruses. Taxa are colored according to their country of origin, and countries are arranged in geographic order from east to west. Arrows indicate viral genomes during 2021 and 2022 in Iceland and assigned to different hemagglutinin clusters B1 and B2. Method hints and basic data are presented in Hassan et al. (13). Scale bar indicates nucleotide substitutions per site.

Figure 2. Phylogeographic tree of highly pathogenic avian influenza viruses. Taxa are colored according to their country of origin, and countries are arranged in geographic order from east to west. Arrows indicate viral genomes during 2021 and 2022 in Iceland and assigned to different hemagglutinin clusters B1 and B2. Method hints and basic data are presented in Hassan et al. (13). Scale bar indicates nucleotide substitutions per site.

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References
  1. Lee  DH, Criado  MF, Swayne  DE. Pathobiological origins and evolutionary history of highly pathogenic avian influenza viruses. Cold Spring Harb Perspect Med. 2021;11:a038679. DOIPubMedGoogle Scholar
  2. Dhingra  MS, Artois  J, Dellicour  S, Lemey  P, Dauphin  G, Von Dobschuetz  S, et al. Geographical and historical patterns in the emergences of novel highly pathogenic avian influenza (HPAI) H5 and H7 viruses in poultry. Front Vet Sci. 2018;5:84. DOIPubMedGoogle Scholar
  3. Lee  DH, Torchetti  MK, Winker  K, Ip  HS, Song  CS, Swayne  DE. Intercontinental spread of Asian-origin H5N8 to North America through Beringia by migratory birds. J Virol. 2015;89:65214. DOIPubMedGoogle Scholar
  4. Global Consortium for H5N8 and Related Influenza Viruses. Role for migratory wild birds in the global spread of avian influenza H5N8. Science. 2016;354:2137. DOIGoogle Scholar
  5. King  J, Harder  T, Globig  A, Stacker  L, Günther  A, Grund  C, et al. Highly pathogenic avian influenza virus incursions of subtype H5N8, H5N5, H5N1, H5N4, and H5N3 in Germany during 2020‒21. Virus Evol. 2022;8:veac025. DOIGoogle Scholar
  6. Pohlmann  A, King  J, Fusaro  A, Zecchin  B, Banyard  AC, Brown  IH, et al. Has epizootic become enzootic? Evidence for a fundamental change in the infection dynamics of highly pathogenic avian influenza in Europe, 2021. MBio. 2022;13:e0060922. DOIPubMedGoogle Scholar
  7. Caliendo  V, Lewis  NS, Pohlmann  A, Baillie  SR, Banyard  AC, Beer  M, et al. Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021. Sci Rep. 2022;12:11729. DOIPubMedGoogle Scholar
  8. US Department of Agriculture, Animal and Plant Health Inspection Service. Detections of highly pathogenic avian influenza in wild birds. 2022 [cited 2022 Aug 4]. https://www.aphis.usda.gov/aphis/ourfocus/animalhealth/animal-disease-information/avian/avian-influenza/hpai-2022/2022-hpai-wild-birds
  9. Bevins  SN, Shriner  SA, Cumbee  JC Jr, Dilione  KE, Douglass  KE, Ellis  JW, et al. Intercontinental movement of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4 virus to the United States, 2021. Emerg Infect Dis. 2022;28:100611. DOIPubMedGoogle Scholar
  10. Gass  JD Jr, Kellogg  HK, Hill  NJ, Puryear  WB, Nutter  FB, Runstadler  JA. Epidemiology and ecology of influenza A viruses among wildlife in the Arctic. Viruses. 2022;14:1531. DOIPubMedGoogle Scholar
  11. Dusek  RJ, Hallgrimsson  GT, Ip  HS, Jónsson  JE, Sreevatsan  S, Nashold  SW, et al. North Atlantic migratory bird flyways provide routes for intercontinental movement of avian influenza viruses. PLoS One. 2014;9:e92075. DOIPubMedGoogle Scholar
  12. Adlhoch  C, Fusaro  A, Gonzales  JL, Kuiken  T, Marangon  S, Niqueux  É, et al.; European Food Safety Authority; European Centre for Disease Prevention and Control; European Union Reference Laboratory for Avian Influenza. Avian influenza overview March - June 2022. EFSA J. 2022;20:e07415.PubMedGoogle Scholar
  13. Hassan  KE, Ahrens  AK, Ali  A, El-Kady  MF, Hafez  HM, Mettenleiter  TC, et al. Improved subtyping of avian influenza viruses using an RT-qPCR-based low density array: ‘Riems Influenza a Typing Array’, Version 2 (RITA-2). Viruses. 2022;14:415. DOIPubMedGoogle Scholar
  14. Pohlmann  A. Iceland as stepping stone for intercontinental spread of highly pathogenic avian influenza H5N1 virus between Europe and North America: data set on phylogeographic analysis, 2022 [cited 2022 Aug 17].
  15. The Guardian. The scale is hard to grasp: avian flu wreaks devastation on sea birds [cited 2022 Oct 18]. https//www.the guardian.com/environment/2022/jul/20/avian-flu-h5n1-wreaks-devastation-seabirds-aoe
  16. Norwegian Veterinary Institute. Avian influenza detected on Svalbard [cited 2022 Oct 18]. https://www.vetinst.no/en/news/avian-influenza-detected-on-svalbard
  17. Columbia Broadcasting System. Avian flu responsible for thousands of dead birds in Newfoundland, suggest preliminary tests [cited 2022 Oct 18]. https://www.cbc.ca/news/canada/newfoundland-labrador/avian-flu-newfoundland-1.6529433
  18. Audubon. Avian flu threatens seabird nesting colonies on both sides of the Atlantic [cited 2022 Oct 18]. https://www.audubon.org/news/avian-flu-threatens-seabid-nesting-colonies-both-sides-atlantic
  19. Krone  O, Globig  A, Ulrich  R, Harder  T, Schinköthe  J, Herrmann  C, et al. White-tailed sea eagle (Haliaeetus albicilla) die-off due to infection with highly pathogenic avian influenza virus, subtype H5N8, in Germany. Viruses. 2018;10:478. DOIPubMedGoogle Scholar
  20. Lean  FZX, Vitores  AG, Reid  SM, Banyard  AC, Brown  IH, Núñez  A, et al. Gross pathology of high pathogenicity avian influenza virus H5N1 2021-2022 epizootic in naturally infected birds in the United Kingdom. One Health. 2022;14:100392. DOIPubMedGoogle Scholar
  21. Loeb  J. Scottish seabirds hit by avian influenza. Vet Rec. 2022;190:488. DOIPubMedGoogle Scholar
  22. Banyard  AC, Lean  FZX, Robinson  C, Howie  F, Tyler  G, Nisbet  C, et al. Detection of highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b in Great Skuas: a species of conservation concern in Great Britain. Viruses. 2022;14:212. DOIPubMedGoogle Scholar
  23. Hill  NJ, Bishop  MA, Trovão  NS, Ineson  KM, Schaefer  AL, Puryear  WB, et al. Ecological divergence of wild birds drives avian influenza spillover and global spread. PLoS Pathog. 2022;18:e1010062. DOIPubMedGoogle Scholar
  24. Stallknecht  DE, Goekjian  VH, Wilcox  BR, Poulson  RL, Brown  JD. Avian influenza virus in aquatic habitats: what do we need to learn? Avian Dis. 2010;54(Suppl):4615. DOIPubMedGoogle Scholar
  25. Centers for Disease Control and Prevention. U.S. case of human avian influenza A(H5) virus reported. 2022 [cited 2022 Jul 7]. https://www.cdc.gov/media/releases/2022/s0428-avian-flu.html

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1These authors contributed equally to this article.

Page created: August 17, 2022
Page updated: November 21, 2022
Page reviewed: November 21, 2022
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