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Volume 28, Number 2—February 2022

Clinical and Laboratory Characteristics and Outcome of Illness Caused by Tick-Borne Encephalitis Virus without Central Nervous System Involvement

Petra BogovičComments to Author , Andrej Kastrin, Stanka Lotrič-Furlan, Katarina Ogrinc, Tatjana Avšič Županc, Miša Korva, Nataša Knap, and Franc Strle
Author affiliations: University Medical Center Ljubljana, Ljubljana, Slovenia (P. Bogovič, S. Lotrič-Furlan, K. Ogrinc, F. Strle); University of Ljubljana, Faculty of Medicine, Ljubljana (A. Kastrin, T. Avšič Županc, M. Korva, N. Knap)

Main Article

Table 1

Demographic and clinical data on adult patients who had febrile illness caused by tick-borne encephalitis virus without central nervous system involvement at the time of evaluation, Slovenia*

Characteristic Value
F 51 (52.0, 41.7–62.2)
47 (48.0, 37.8–58.3)
Median age, y (IQR)
51 (37–60.75)
Underlying illnesses
38 (38.8, 29.1–49.2)
History of tick bite†
86 (88.7, 80.6–94.2)
Median incubation period, d (IQR)‡
6 (4–9.75)
Median duration of illness before first evaluation, d (IQR)
5 (4–6)
Clinical manifestation
Body temperature >37.5°C 95 (96.9, 91.3–99.4)
Median body temperature, °C (IQR)§ 38.3 (37.8–38.9)
Chills 19 (19.4, 12.1–28.6)
Headache 84 (85.7, 77.2–92.0)
Myalgia 53 (54.1, 43.7–64.2)
Arthralgia 42 (42.9, 32.9–53.3)
Gastrointestinal symptoms 45 (45.9, 35.8–56.3)
Abdominal pain 2 (2.0, 0.3–7.2)
Nausea, vomiting 37 (37.8, 28.2–48.1)
Diarrhea 16 (16.3, 9.6–25.2)
Malaise and fatigue 96 (98.0, 92.8–99.8)
Respiratory symptoms 18 (18.4, 11.3–27.5)
Sore throat 11 (11.2, 5.7–19.2)
10 (10.2, 5.0–18.0)
Median duration of illness, initial phase, d (IQR)¶
7 (6–8)
No. hospitalized patients 37 (37.8, 28.2–48.1)
Median duration of hospitalization, d (IQR)# 3 (1–5)

*Values are no. (%, 95% CI) except as indicated. IQR, interquartile range. †Tick bite within 4 weeks before onset of illness. Data available for 97 patients. ‡Time (days) from tick bite to onset of illness calculated only in patients with 1 bite. Data available for 54 patients. §Highest temperature in the course of the illness. ¶Data available for 82 patients. #Data available for 33 patients.

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Page created: December 02, 2021
Page updated: January 21, 2022
Page reviewed: January 21, 2022
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