Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 28, Number 3—March 2022
Research Letter

Serial Intervals and Household Transmission of SARS-CoV-2 Omicron Variant, South Korea, 2021

Jin Su Song1, Jihee Lee1, Miyoung Kim, Hyeong Seop Jeong, Moon Su Kim, Seong Gon Kim, Han Na Yoo, Ji Joo Lee, Hye Young Lee, Sang-Eun Lee, Eun Jin Kim, Jee Eun Rhee, Il Hwan Kim, and Young-Joon ParkComments to Author 
Author affiliations: Capital Regional Center for Disease Control and Prevention, Seoul, South Korea (J.S. Song, J. Lee, M. Kim); Incheon Metropolitan Government, Incheon, South Korea (H.S. Jeong, M.S. Kim, S.G. Kim, H.N. Yoo); Korea Disease Control and Prevention Agency, Cheongju, South Korea (J.J. Lee, H.Y. Lee, S.-E. Lee, E.J. Kim, J.E. Rhee, I.H. Kim, Y.-J. Park)

Cite This Article


To clarify transmissibility of the severe acute respiratory syndrome coronavirus 2 Omicron variant, we determined serial intervals and secondary attack rates among household contacts in South Korea. Mean serial interval for 12 transmission pairs was 2.9 days, and secondary attack rate among 25 households was 50.0%, raising concern about a rapid surge in cases.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant of concern has been confirmed on all continents and has spread through communities around the world at unprecedented speed (1). Given uncertainties about current estimates of virus transmissibility, we analyzed real-life data on serial intervals for transmission pairs (time from infector symptom onset to infectee symptom onset) and secondary attack rate among household contacts, offering metrics essential for predicting epidemic size, forecasting healthcare demand, and devising effective public health interventions. Details of the epidemiologic situation with regard to importation and transmission of the Omicron variant in South Korea have been described elsewhere (2). We further traced a total of 76 case-patients with Omicron infection that originated from 2 persons with imported cases (75 confirmed cases and 1 suspected case) and their contacts, focusing on infector-infectee relationships and household transmission during November–December 2021.

Because of the possibility of their being exposed to other potential sources of infection at church on November 28, 2021, we excluded infectees who had visited church on that date from transmission pairs. As for the time of infection in households, we assumed that the earliest exposure occurred 2 days before symptom onset of an infector and the last exposure before isolation of the infector. To calculate serial intervals, we did not include case-patients without a clear date of symptom onset. We defined a household as a group of persons living in the same residence with a shared space. This study was conducted as a legally mandated public health investigation under the authority of the Korean Infectious Diseases Control and Prevention Act (no. 12444 and no. 13392). The study was not research that was subject to institutional review board approval; therefore, written informed consent was not required.

We identified 25 households, comprising 55 household members. Only 1 household comprised South Korea nationals; the others, foreign nationals. Of the 55 household members, 36 were confirmed to be Omicron-positive, among which secondary attack rate was 0.65 (95% CI 0.48–0.81). After we excluded the 18 household members who had visited church on November 28, 2021, the remaining 18 were confirmed to be Omicron case-patients; secondary attack rate among the 18 was 0.50 (95% CI 0.35–0.72) (Table).

We used 12 transmission pairs for the calculation, including 12 infectors and 19 infectees. Mean (± SD) ages were 34.2 (± 18.2) years for infectors and 32.5 (± 21.7) years for infectees. The mean incubation period of the transmission pairs was 2.5–4.3 days, and the median incubation period was 3–4 days. The mean (± SD) serial interval for the pairs was 2.9 (± 1.6) days; the median serial interval was 3.0 days (Appendix).

The estimated mean serial interval of 2.9 days for Omicron was shorter than that determined for wild-type virus and the Delta variant found in other studies conducted in South Korea (3,4). Enhanced nonpharmaceutical interventions such as rapid isolation of case-patients, as revealed by the mean time of 0.75 (range 0–4) days from symptom onset to isolation among infectors, and meticulous contact tracing during the study period may have shortened the serial interval and reduced superspreading potential, as evidenced in other research (5). Thus, further studies in other places or at other periods, are needed, using larger sample sizes to more accurately estimate transmission dynamics and effects of public health measures.

The household secondary attack rate that we found, factoring in vaccination status and prior infections, was substantially higher than rates for wild type virus and the Delta variant of concern previously reported in South Korea and other countries (6). This finding is in line with earlier reports that suggested increased household risk for transmission of Omicron variant (7,8), although enhanced isolation in conjunction with a comprehensive testing strategy for contacts of case-patients may partially inflate secondary attack rate in our study. Of note, in our study, the secondary attack rate among fully vaccinated persons is high (62.5%, 10/16), thus heightening concerns over immune escape and the possibility that Omicron may be associated with considerably reduced vaccine effectiveness. However, further studies are needed to accurately assess the relative roles of increased intrinsic transmissibility and immune escape.

Our findings with regard to Omicron transmissibility by symptomatic index case-patients supports that of a meta-analysis reporting that that secondary attack rates were higher in households with symptomatic rather than asymptomatic index case-patients (6). However, caution is warranted when interpreting our results because other social and demographic factors could not be properly adjusted and sample size was too small to ensure adequate statistical power. Our findings of a short serial interval among transmission pairs and a high secondary attack rate among household members adds timely real-life evidence of increased transmissibility of the Omicron variant of concern along with the potential for immune escape, thus necessitating a package of effective public health measures to mitigate the spread of Omicron in each country.

Dr. Song is an infectious disease specialist at the Korea Disease Control and Prevention Agency and an adjunct professor of global health at Handong Global University. His research interests focus on design, implementation, and evaluation of infectious diseases program in low-income countries. Dr. J. Lee is a public health officer at the Korea Disease Control and Prevention Agency, whose main research addresses epidemiologic investigation and surveillance measures of infectious diseases and strengthening health systems.



We thank the relevant ministries, including the Ministry of Interior and Safety, Si/Do and Si/Gun/Gu, medical staff in health centers, and medical facilities for their efforts in responding to the coronavirus disease outbreak.

The opinions expressed by authors contributing to this article do not necessarily reflect the opinions of the Korea Disease Control and Prevention Agency or the institutions with which the authors are affiliated. The authors declare that there is neither conflict of interest nor financial support for this work.



  1. World Health Organization. Enhancing response to SARS-CoV-2 Omicron variant [cited 2021 Dec 23].
  2. Lee  JJ, Choe  YJ, Jeong  H, Kim  M, Kim  S, Yoo  H, et al. Importation and transmission of SARS-CoV-2 B.1.1.529 (Omicron) variant of concern in Korea, November 2021. J Korean Med Sci. 2021;36:e346. DOIPubMedGoogle Scholar
  3. Hong  K, Yum  S, Kim  J, Chun  BC. The serial interval of COVID-19 in Korea: 1,567 pairs of symptomatic cases from contact tracing. J Korean Med Sci. 2020;35:e435. DOIPubMedGoogle Scholar
  4. Ryu  S, Kim  D, Lim  JS, Ali  ST, Cowling  BJ. Serial interval and transmission dynamics during SARS-CoV-2 Delta variant predominance, South Korea. Emerg Infect Dis. 2022 Feb [cited 2021 Dec 22].
  5. Ali  ST, Wang  L, Lau  EHY, Xu  XK, Du  Z, Wu  Y, et al. Serial interval of SARS-CoV-2 was shortened over time by nonpharmaceutical interventions. Science. 2020;369:11069. DOIPubMedGoogle Scholar
  6. Madewell  ZJ, Yang  Y, Longini  IM Jr, Halloran  ME, Dean  NE. Household transmission of SARS-CoV-2: a systematic review and meta-analysis. JAMA Netw Open. 2020;3:e2031756. DOIPubMedGoogle Scholar
  7. European Centre for Disease Prevention and Control. Assessment of the future emergence and potential impact of the SARS-CoV-2 Omicron variant of concern in the context of ongoing transmission of the Delta variant of concern in the EU/EEA, 18th update [cited 2021 Dec 23].
  8. UK Health Security Agency. SARS-CoV-2 variants of concern and variants under investigation in England: technical briefing 32 [cited 2021 Dec 22].




Cite This Article

DOI: 10.3201/eid2803.212607

Original Publication Date: February 02, 2022

1These authors contributed equally to this article.

Table of Contents – Volume 28, Number 3—March 2022

EID Search Options
presentation_01 Advanced Article Search – Search articles by author and/or keyword.
presentation_01 Articles by Country Search – Search articles by the topic country.
presentation_01 Article Type Search – Search articles by article type and issue.



Please use the form below to submit correspondence to the authors or contact them at the following address:

Young-Joon Park, Director of Epidemiologic Investigation, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 28159, South Korea

Send To

10000 character(s) remaining.


Page created: January 26, 2022
Page updated: February 21, 2022
Page reviewed: February 21, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.