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Volume 29, Number 10—October 2023
Research

Posttransfusion Sepsis Attributable to Bacterial Contamination in Platelet Collection Set Manufacturing Facility, United States

Ian Kracalik, Alyssa G. Kent, Carlos H. Villa, Paige Gable, Pallavi Annambhotla, Gillian McAllister, Deborah Yokoe, Charles R. Langelier, Kelly Oakeson, Judith Noble-Wang, Orieji Illoh, Alison Laufer Halpin, Anne F. Eder, and Sridhar V. BasavarajuComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (I. Kracalik, A.G. Kent, P. Gable, P. Annambhotla, G. McAllister, J. Noble-Wang, A.L. Halpin, S.V. Basavaraju); Food and Drug Administration, Silver Spring, Maryland, USA (C.H. Villa, O. Illoh, A.F. Eder); University of California San Francisco School of Medicine, San Francisco, California, USA (D. Yokoe, C.R. Langelier); Utah Department of Health, Salt Lake City, Utah, USA (K. Oakeson)

Main Article

Table

Characteristic of confirmed and probable transfusion-transmitted sepsis associated with bacterially contaminated platelet products for 7 patients, United States, 2018–2021*

Characteristic
 Patient A
 Patient B
 Patient C
 Patient D
 Patient E
 Patient F
 Patient G
Sex M M M M M F F
State CA UT CT CT NC OH VA
Year 2018 2018 2018 2018 2020 2021 2021
Posttransfusion clinical status
 Alive
 Deceased
 Alive
 Alive
 Deceased
 Deceased
 Alive
Platelet collection system Amicus Amicus Amicus Amicus Amicus Amicus Amicus
Platelet storage media PA PAS PAS PAS PAS PAS PAS
Bacterial control strategy PR PC PC, RT PC, RT PR PR PR
Platelet age, d 5 5 4 4 5 5 4
Platelet co-component transfused
 No
 No
 Yes
 Yes
 Yes
 Yes
 Yes
Posttransfusion cultures
Patient blood
ACBC Yes Yes Yes Yes Yes Yes No
Staphylococcus saprophyticus No No Yes Yes Yes Yes No
Leclercia adecarboxylata No No No No Yes No No
Enterobacter spp. No No No No No No Yes
Transfused platelet product
ACBC Yes Yes Yes Yes Yes Yes No
S. saprophyticus Yes No Yes Yes Yes Yes Yes
L. adecarboxylata No No No No Yes Yes Yes
Enterobacter spp. No No No No No No Yes
Bacillus spp.
 No
 No
 No
 No
 No
 Yes
 No
Signs and symptoms
Fever Yes Yes Yes Yes Yes No Yes
Hypotension Yes Yes Yes Yes Yes Yes Yes
Chills Yes Yes Yes Yes No No Yes
Tachycardia or bradycardia Yes Yes No No Yes Yes Yes

*Platelets were stored in a combination of platelet additive solution and plasma. Patients C and D received platelet components from the same platelet collection. Amicus platelet collection sets and associated solutions (saline and anticoagulant) are manufactured by Fenwal International, Inc., a Fresenius Kabi Company (https://www.fresenius-kabi.com). ACBC, Acinetobacter calcoaceticus‒baumannii complex; PAS, platelet additive solution; PC, primary culture; PR, pathogen reduction; RT, secondary rapid test.

Main Article

Page created: August 02, 2023
Page updated: September 20, 2023
Page reviewed: September 20, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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