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Volume 29, Number 11—November 2023
Research Letter

Case of Carbapenem-Resistant Salmonella Typhi Infection, Pakistan, 2022

Summiya NizamuddinComments to Author , Ejaz Ahmed Khan, Marie Anne Chattaway, and Gauri Godbole
Author affiliations: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan (S. Nizamuddin); Shifa International Hospital at Shifa Tameer-e-Millat University, Islamabad, Pakistan (E.A. Khan); UK Health Security Agency, London, United Kingdom (M.A. Chattaway, G. Godbole)

Main Article

Table

MICs and antimicrobial drug resistance determinants of Salmonella Typhi isolated from patient during clinical disease relapse of carbapenem-resistant Salmonella Typhi infection, Pakistan, 2022*

Antimicrobial drug
 1790097 (variant 1)
1790125 (variant 2)
Gene/ mutation
 MIC, μg/L
 Gene/mutation
 MIC, μg/L
Ampicillin blaNDM-5, blaTEM-1 32 blaNDM-5, blaTEM-1, blaCTX-M-15 32
Azithromycin mphA 64 mphA 64
Cefoxitin blaNDM-5 64 blaNDM-5 64
Tetracycline tetA 32 tetA 32
Tigecycline NA 0.25 NA 0.25
Ertapenem blaNDM-5 2 blaNDM-5 2
Imipenem blaNDM-5 16 blaNDM-5 16
Meropenem blaNDM-5 16 blaNDM-5 16
Cefotaxime blaNDM-5 64 blaNDM-5, blaCTX-M-15 64
Ceftazidime blaNDM-5 128 blaNDM-5, blaCTX-M-15 128
Cefepime blaNDM-5 32 blaNDM-5, blaCTX-M-15 32
Nalidixic acid gyrA [83:S-F] 64 gyrA [83:S-F], qnrS1 64
Ciprofloxacin gyrA [83:S-F] 1 gyrA [83:S-F], qnrS1 8
Chloramphenicol NA 8 catA 64
Trimethoprim dfrA-27, dfrA-7 16 dfrA-27, dfrA-7 16
Sulfonamide sul-1 512 sul-1 512
Amikacin aac(6')-Ib-cr, aac(6')-Ia <4 aac(6')-Ib-cr, aac(6')-Ia 8
Gentamicin aac(6')-Ib-cr, aadA-16, aac(6')-Iy <0.5 aac(6')-Ib-cr, aadA-16, aac(6')-Iy <0.5
Temocillin blaNDM-5 128 blaNDM-5 128
Colistin NA 1 NA 1

*Boldface indicates additional genes detected and increased MIC values for variant 2. NA, not applicable.

Main Article

Page created: October 05, 2023
Page updated: October 23, 2023
Page reviewed: October 23, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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