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Volume 29, Number 12—December 2023
Research

Tecovirimat Resistance in Mpox Patients, United States, 2022–2023

Todd G. SmithComments to Author , Crystal M. Gigante, Nhien T. Wynn, Audrey Matheny, Whitni Davidson, Yong Yang, Rene Edgar Condori, Kyle O’Connell, Lynsey Kovar, Tracie L. Williams, Yon C. Yu, Brett W. Petersen, Nicolle Baird, David Lowe, Yu Li, Panayampalli S. Satheshkumar, and Christina L. Hutson
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (T.G. Smith, C.M. Gigante, N.T. Wynn, A. Matheny, W. Davidson, Y. Yang, R.E. Condori, K. O’Connell, L. Kovar, T.L. Williams, Y.C. Yu, B.W. Petersen, N. Baird, D. Lowe, Y. Li, P.S. Satheshkumar, C.L. Hutson); Deloitte Consulting LLC, Arlington, Virginia, USA (K. O’Connell); Leidos Inc., Reston, Virginia, USA (L. Kovar)

Main Article

Table 1

Surveillance for tecovirimat resistance in mpox cases, United States, 2023*

Category
 No. samples or isolates
 No. patients
Genomic testing
Sequences analyzed 3,247
F13 substitutions other than E353K found (Table 2)
 130
 76
Phenotype testing
Submitted to CDC 801 435
MPXV isolated 164 83
Phenotype testing complete 124 68
Tecovirimat resistant
 96
46
HIV-positive 39
CD4+ T-cell count <350 cell/µL 31
CD4+ T-cell count <200 cell/µL
28
Deceased 10
Hospitalized 34
Tecovirimat treated 39

*CDC, Centers for Disease Control and Prevention; MPXV, monkeypox virus.

Main Article

Page created: October 18, 2023
Page updated: November 18, 2023
Page reviewed: November 18, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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