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Volume 30, Number 1—January 2024
Research

Doxycycline Prophylaxis for Skin and Soft Tissue Infections in Naval Special Warfare Trainees, United States1

Jeffrey SpiroComments to Author , Piotr WisniewskiComments to Author , Julia Schwartz, Alfred G. Smith, Sara Burger, Drake H. Tilley, and Ryan C. Maves
Author affiliations: Naval Medical Center, San Diego, California, USA (J. Spiro, P. Wisniewski, D.H. Tilley, R.C. Maves); Naval Health Research Center, San Diego (P. Wisniewski); Naval Special Warfare Center, Coronado, California, USA (J. Schwartz, S. Burger); Naval Medical Center, Portsmouth, Virginia, USA (A.G. Smith); Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA (R.C. Maves)

Main Article

Table 1

Primary and secondary outcome data in study of doxycycline prophylaxis for SSTIs in Naval Special Warfare trainees, United States*

Outcome Preprophylaxis Postprophylaxis Rate ratio (95% CI) p value
Hospital admission rate per 100 trainees 1.37 (14/1,024) 0.64 (15/2,347) 0.468 (0.226–0.968) 0.036
  Mean hospital admission length, d 9.07 4.33 NA 0.034
Overall SSTI incidence rate per 100 trainees 7.42 (76/1,024) 8.86 (208/2,347) 1.19 (0.918– 1.55) 0.185
Hospital admission rate per diagnosed SSTI 18.4 (14/76) 7.2 (15/208) 0.392 (0.189–0.811) 0.0089

*Values are % (no. patients/total no. in category) except as indicated. NA, not applicable; SSTI, skin and soft tissue infection.

Main Article

1Preliminary findings were presented at IDWeek 2019, Washington, DC, USA, October 2–6, 2019.

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