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Volume 30, Number 3—March 2024
CME ACTIVITY - Research

Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection

Paulo R.L. MachadoComments to Author , Alexsandro Lago, Thiago M. Cardoso, Andréa Magalhaes, Lucas P. Carvalho, Tainã Lago, Augusto M. Carvalho, Rúbia Costa, and Edgar M. Carvalho
Author affiliations: Federal University of Bahia, Salvador, Brazil (P.R.L. Machado, A. Lago, A. Magalhaes, L.P. Carvalho, T. Lago, R. Costa, E.M. Carvalho); National Institute of Science and Technology of Tropical Diseases (INCT-DT), Brasília, Brazil (P.R.L. Machado, L.P. Carvalho, A.M. Carvalho, E.M. Carvalho); Fiocruz, Salvador (T.M. Cardoso, A. Magalhaes, L.P. Carvalho, A.M. Carvalho, R. Costa, E.M. Carvalho)

Main Article

Table 2

Demographic, clinical, laboratory, and therapeutic aspects of DL patients according to number of lesions in study of leishmaniasis immune response and clinical and therapeutic outcomes, Corte de Pedra Health Post, Brazil, 2016–2019*

Characteristic DL with >50 lesions, n = 40 DL with <40 lesions, n = 55 p value
Age, y 44.5 + 13.3 35.3 + 14.2 0.0018†
Sex
M 34 (85) 49 (89) NS
F 6 (15) 6 (11) NS
Duration of disease, d 46 + 3.4 58 + 4.0 0.031†
Dissemination time, d 21 + 2.3 26 + 4.4 0.40†
Systemic symptoms, no. positive/no. tested (%) 29/38 (76) 28/40 (70) NS
No. lesions 252 + 45.1 22 + 1.0 <0.0001†
Largest lesion area, mm2 1181 + 581.2 905 + 415.3 0.69#
Lymphadenopathy, no. positive/no. tested (%) 13/26 (50) 25/51 (49) NS
Mucosal involvement, no. positive/no. tested (%) 16/36 (44.4) 12/39 (31) NS
LST area, mm2 156 + 84.7 141 + 71.4 0.47†
LST, no. positive/no. tested (%) 24/39 (62) 36/54 (67) NS
PCR, no. positive/no. tested (%) 24/26 (92) 44/49 (90) NS
Cure rate, no. cured/no. treated (%)‡ 7/21 (33) 23/41 (56) 0.03§
Healing time, d 218 + 203 109 + 95 0.0018†

*Values are no. (%) or mean + SD unless otherwise indicated. DL, disseminated leishmaniasis; LST, Leishmania skin test, NS, not significant. †By unpaired t-test. ‡After 1 standard course of meglumine antimoniate (20 mg/kg/d) for 30 d. §By Fisher exact test.

Main Article

Page created: January 26, 2024
Page updated: February 23, 2024
Page reviewed: February 23, 2024
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