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Volume 30, Number 4—April 2024
Research

Divergent Pathogenesis and Transmission of Highly Pathogenic Avian Influenza A(H5N1) in Swine

Bailey ArrudaComments to Author , Amy L. Vincent Baker, Alexandra Buckley, Tavis K. Anderson, Mia Torchetti, Nichole Hines Bergeson, Mary Lea Killian, and Kristina Lantz
Author affiliations: Agriculture Research Service, Ames, Iowa, USA (B. Arruda, A.L. Vincent Baker, A. Buckley, T.K. Andersen); Animal and Plant Health Inspection Service, Ames (M. Torchetti, N. Hines Bergeson, M.L. Killian, K. Lantz)

Main Article

Figure 8

Violin plots of airway conducting IHC scores, by virus strain and dpi, of swine infected with highly pathogenic avian influenza A(H5N1) virus belonging to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade. A) Lung conducting airway immunohistochemical scores. Influenza A virus (IAV) nucleoprotein (NP) antigen detection varied by group with the most extensive labeling (the number of positive pigs) being observed in the A/bald eagle/FL/22 and A/red fox/MI/22 groups. B) Lung nonconducting airway immunohistochemical scores. IAV NP antigen detection varied by group with the most extensive labeling being observed in the A/bald eagle/FL/22. Solid lines within plots indicate medians, dashed lines indicate quartiles, and symbols indicate individual pig values. dpi, days postinoculation; eagle 3 dpi, A/bald eagle/FL/22 necropsied at 3 dpi; eagle 5 dpi, A/bald eagle/FL/22 necropsied at 5 dpi; fox 3 dpi, A/redfox/MI/22 necropsied at 3 dpi; fox 5 dpi, A/redfox/MI/22 necropsied at 5 dpi; IHC, immunohistochemistry; racoon 3 dpi, A/raccoon/WA/22 necropsied at 3 dpi; racoon 5 dpi, A/raccoon/WA/22 necropsied at 5 dpi; turkey 3 dpi, A/turkey/MN/22 necropsied at 3 dpi; turkey 5 dpi, A/turkey/MN/22 necropsied at 5 dpi.

Figure 8. Violin plots of airway conducting IHC scores, by virus strain and dpi, of swine infected with highly pathogenic avian influenza A(H5N1) virus belonging to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade. A) Lung conducting airway immunohistochemical scores. Influenza A virus (IAV) nucleoprotein (NP) antigen detection varied by group with the most extensive labeling (the number of positive pigs) being observed in the A/bald eagle/FL/22 and A/red fox/MI/22 groups. B) Lung nonconducting airway immunohistochemical scores. IAV NP antigen detection varied by group with the most extensive labeling being observed in the A/bald eagle/FL/22. Solid lines within plots indicate medians, dashed lines indicate quartiles, and symbols indicate individual pig values. dpi, days postinoculation; eagle 3 dpi, A/bald eagle/FL/22 necropsied at 3 dpi; eagle 5 dpi, A/bald eagle/FL/22 necropsied at 5 dpi; fox 3 dpi, A/redfox/MI/22 necropsied at 3 dpi; fox 5 dpi, A/redfox/MI/22 necropsied at 5 dpi; IHC, immunohistochemistry; racoon 3 dpi, A/raccoon/WA/22 necropsied at 3 dpi; racoon 5 dpi, A/raccoon/WA/22 necropsied at 5 dpi; turkey 3 dpi, A/turkey/MN/22 necropsied at 3 dpi; turkey 5 dpi, A/turkey/MN/22 necropsied at 5 dpi.

Main Article

Page created: March 07, 2024
Page updated: March 20, 2024
Page reviewed: March 20, 2024
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