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Volume 30, Number 4—April 2024
Research Letter

Link between Monkeypox Virus Genomes from Museum Specimens and 1965 Zoo Outbreak

Michelle HämmerleComments to Author , Aigerim Rymbekova, Pere Gelabert, Susanna Sawyer, Olivia Cheronet, Paolo Bernardi, Sébastien Calvignac-Spencer, Martin Kuhlwilm1, Meriam Guellil1, and Ron Pinhasi1Comments to Author 
Author affiliations: University of Vienna, Vienna, Austria (M. Hämmerle, A. Rymbekova, P. Gelabert, S. Sawyer, O. Cheronet, P. Bernardi, M. Kuhlwilm, M. Guellil, R. Pinhasi); Helmholtz Centre for Infection Research, Greifswald, Germany (S. Calvignac-Spencer); University of Greifswald, Greifswald (S. Calvignac-Spencer)

Main Article

Figure

Maximum-likelihood phylogeny tree showing the close relation between MPXV genomes from museum orangutan samples from Germany (bold text), which fall into clade IIa, to the genome derived from the MPXV zoo outbreak in Rotterdam, the Netherlands, 1965. The phylogeny tree is rooted on the outgroup genome (GenBank accession no. NC_003310) from clade I with the museum orangutan genomes MAM1965–545 and MAM1965–547. The consensus sequences for the ancient sequences are based on a mapping to the Rotterdam genome. The final single-nucleotide polymorphisms alignment length was 138,240 bp. The collapsed node contains genomes from Pan troglodytes verus from Cote d’Ivoire (GenBank accession nos. MN346690, MN346692, MN346694–8, MN346700–1).

Figure. Maximum-likelihood phylogeny tree showing the close relation between MPXV genomes from museum orangutan samples from Germany (bold text), which fall into clade IIa, to the genome derived from the MPXV zoo outbreak in Rotterdam, the Netherlands, 1965. The phylogeny tree is rooted on the outgroup genome (GenBank accession no. NC_003310) from clade I with the museum orangutan genomes MAM1965–545 and MAM1965–547. The consensus sequences for the ancient sequences are based on a mapping to the Rotterdam genome. The final single-nucleotide polymorphisms alignment length was 138,240 bp. The collapsed node contains genomes from Pan troglodytes verus from Cote d’Ivoire (GenBank accession nos. MN346690, MN346692, MN346694–8, MN346700–1).

Main Article

1These authors contributed equally to this article.

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