Volume 4, Number 2—June 1998
Dispatch
Clostridium septicum Infection and Hemolytic Uremic Syndrome
Table
Hemolytic uremic syndrome–associated Clostridium septicum infection
Cytopeniasc |
||||||
---|---|---|---|---|---|---|
Country, year (ref) | Sex,a age (yrs) | E.colib in feces | Cl. Septicum isolated from | granulo- | thrombo- | Clinical features–outcome |
USA, 1988 (8) | M, 1 | NSd | Rash aspirate, PMe blood | No | Yes | Abdominal rash, sepsis, convulsions, cerebritis, necrosis colon—died |
England, 1993 (9) | M, 4 | O157 | Blood, PM brain | No | Yes | Convulsions, cerebritis, necrosis colon—died |
USA, 1993 (10) | F, 2 | E. coli | Blood, cerebrospinal fluid | No | Yes | Sepsis, cerebritis, meningitis, necrosis colon—died |
USA, 1995 (11) | M, 2 | O157 | Abscess pus | No | Yes | Brain abscess—recovered |
England, 1997 (this study) | M, 2 | O157 | Blood | No | Yes | Septic shock—died |
a M, male; F, female.
bEscherichia coli.
cAt HUS = at the time that hemolytic uremic syndrome was evident.
dNS, not stated.
ePM, postmortem.
References
- Sebald M, Hauser D. Pasteur, oxygen and the anaerobes revisited. Anaerobe. 1995;1:11–6. DOIPubMedGoogle Scholar
- MacLennan JD. Histotoxic clostridial infections of man. Bacteriol Rev. 1962;26:176–276.
- Koransky JR, Stargel MD, Dowell VR. Clostridium septicum bacteremia—its clinical significance. Am J Med. 1979;66:63–6. DOIPubMedGoogle Scholar
- Stevens DL, Musher DM, Watson DA, Eddy H, Hamill RJ, Gyorkey F, Spontaneous, nontraumatic gangrene due to Clostridium septicum. Rev Infect Dis. 1990;12:286–96.PubMedGoogle Scholar
- Kornbluth AA, Danzig JB, Bernstein LH. Clostridium septicum infection and associated malignancy. Medicine. 1989;68:30–7. DOIPubMedGoogle Scholar
- Caya JG, Farmer SG, Ritch PS, Wollenberg NJ, Tieu TM, Oechler HW, Clostridial septicemia complicating the course of leukemia. Cancer. 1986;57:2045–8. DOIPubMedGoogle Scholar
- Riccio JA, Oberkircher OR. Clostridium septicum sepsis and cerebritis: a rare complication of the hemolytic-uremic syndrome. Pediatr Infect Dis J. 1988;7:342–5. DOIPubMedGoogle Scholar
- Randall JM, Hall K, Coulthard MG. Diffuse pneumocephalus due to Clostridium septicum cerebritis in hemolytic uremic syndrome. Neuroradiology. 1993;35:218–20. DOIPubMedGoogle Scholar
- Broughton RA, Lee EY. Clostridium septicum sepsis and meningitis as a complication of the hemolytic-uremic syndrome. Clin Pediatr (Phila). 1993;32:750–2. DOIPubMedGoogle Scholar
- Chiang V, Adelson PD, Poussaint TY, Hand M, Churchwell KB. Brain abscess caused by Clostridium septicum as a complication of hemolytic-uremic syndrome. Pediatr Infect Dis J. 1995;14:72–4. DOIPubMedGoogle Scholar
- Yeaman MR. The role of platelets in antimicrobial host defense. Clin Infect Dis. 1997;25:951–70. DOIPubMedGoogle Scholar
- Lorber B. Gas gangrene and other clostridium-associated diseases. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. 4th ed. New York: Churchill Livingstone; 1995. p. 2182-95.
- George WL, Finegold SM. Clostridia in the human gastrointestinal flora. In: Borriello SP, editor. Clostridia in gastrointestinal disease. Boca Raton (FL): CRC Press; 1985. p. 1-37.
- Radostits OM, Blood DC, Gay CC. Veterinary medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses. 8th ed. London: Bailliere Tindall; 1994. p. 686-9.
- Martin WB, Aitken ID. Diseases of sheep. 2nd ed. Oxford: Blackwell Scientific Publications; 1991. p. 109-13.