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Volume 6, Number 3—June 2000
Perspective

A Dynamic Transmission Model for Predicting Trends in Helicobacter pylori and Associated Diseases in the United States

Marcia F.T. Rupnow*Comments to Author , Ross D. Shachter*, Douglas K. Owens*†, and Julie Parsonnet*
Author affiliations: *Stanford University, Stanford, California, USA; †Department of Veterans Affairs Health Care System, Palo Alto, California, USA

Main Article

Figure 3

Simulated temporal change in Helicobacter pylori and associated diseases. a) Prevalence of H. pylori in the U.S. population by age category (simulation output). b) Incidence of DU and GC per 100,000 U.S. population. "Hp GC" and "Hp DU" are simulation outputs. "SEER GC" represents incidence of GC from all cases, from the Surveillance, Epidemiology, and End Results report (25). "NCHS GC" represents incidence of GC from all cases, derived from the mortality statistics published by the National Cent

Figure 3. Simulated temporal change in Helicobacter pylori and associated diseases. a) Prevalence of H. pylori in the U.S. population by age category (simulation output). b) Incidence of DU and GC per 100,000 U.S. population. "Hp GC" and "Hp DU" are simulation outputs. "SEER GC" represents incidence of GC from all cases, from the Surveillance, Epidemiology, and End Results report (25). "NCHS GC" represents incidence of GC from all cases, derived from the mortality statistics published by the National Center for Health Statistics and the Bureau of the Census (28). "Kurata et al. DU" represents incidence of DU from all cases, based on data from a large health maintenance organization in Southern California (34). The simulation model predicted that the prevalence of H. pylori, as well as incidence of H. pylori-associated DU and GC, would continue to decrease in the 21st century.

Main Article

References
  1. Taylor  DN, Parsonnet  J. Epidemiology and natural history of Helicobacter pylori infection. In: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL, editors. Infections of the gastrointestinal tract. New York: Raven Press; 1995. p. 551-63.
  2. NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. JAMA. 1994;272:659. DOIPubMedGoogle Scholar
  3. Telford  JL, Ghiara  P. Prospects for the development of a vaccine against Helicobacter pylori. Drugs. 1996;52:799804. DOIPubMedGoogle Scholar
  4. Lee  A. Vaccination against Helicobacter pylori. J Gastroenterol. 1996;31(Suppl 9):6974. DOIPubMedGoogle Scholar
  5. Parsonnet  J, Blaser  MJ, Perez-Perez  GI, Hargrett-Bean  N, Tauxe  RV. Symptoms and risk factors of Helicobacter pylori infection in a cohort of epidemiologists. Gastroenterology. 1992;102:416.PubMedGoogle Scholar
  6. Banatvala  N, Mayo  K, Megraud  F, Jennings  R, Deeks  JJ, Feldman  RA. The cohort effect and Helicobacter pylori. J Infect Dis. 1993;168:21921.PubMedGoogle Scholar
  7. Parsonnet  J. The incidence of Helicobacter pylori infection. Aliment Pharmacol Ther. 1995;9(Suppl 2):4551.PubMedGoogle Scholar
  8. Anderson  RM, May  RM. Infectious diseases of humans: dynamics and control. New York: Oxford University Press; 1991.
  9. Kuipers  EJ. Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther. 1997;11(Suppl 1):7188. DOIPubMedGoogle Scholar
  10. Graham  DY. Helicobacter pylori: its epidemiology and its role in duodenal ulcer disease. J Gastroenterol Hepatol. 1991;6:10513. DOIPubMedGoogle Scholar
  11. Schultze  V, Hackelsberger  A, Günther  T, Miehlke  S, Roessner  A, Malfertheiner  P. Differing patterns of Helicobacter pylori gastritis in patients with duodenal, prepyloric, and gastric ulcer disease. Scand J Gastroenterol. 1998;33:13742. DOIPubMedGoogle Scholar
  12. Sonnenberg  A. Temporal trends and geographical variations of peptic ulcer disease. Aliment Pharmacol Ther. 1995;9(Suppl 2):312.PubMedGoogle Scholar
  13. Sipponen  P, Kekki  M, Haapakoski  J, Ihamäki  T, Siurala  M. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int J Cancer. 1985;35:1737. DOIPubMedGoogle Scholar
  14. Sipponen  P. Helicobacter pylori gastritis--epidemiology. J Gastroenterol. 1997;32:2737. DOIPubMedGoogle Scholar
  15. Hansson  LE, Nyrén  O, Hsing  AW, Bergström  R, Josefsson  S, Cho  WH, The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 1996;335:2429. DOIPubMedGoogle Scholar
  16. Blaser  MJ, Chyou  PH, Nomura  A. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res. 1995;55:5625.PubMedGoogle Scholar
  17. Correa  P, Cuello  C, Duque  E, Burbano  LC, Garcia  F, Bolanos  O, Gastric cancer in Colombia. III. Natural history of precursor lesions. J Natl Cancer Inst. 1976;57:102735.PubMedGoogle Scholar
  18. U.S. National Office of Vital Statistics. Abridged life tables--United States, 1950. Vital Statistics--Special Reports 1953;37:333-43.
  19. Gibson  C. Population of the 100 largest cities and other urban places in the United States: 1790 to 1990: U.S. Census Bureau, 1998. Available from: URL: http://www.census.gov/population/www/documentation/twps0027.html.
  20. Feldman  RA, Eccersley  AJ, Hardie  JM. Epidemiology of Helicobacter pylori: acquisition, transmission, population prevalence and disease-to-infection ratio. Br Med Bull. 1998;54:3953.PubMedGoogle Scholar
  21. Graham  DY. Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model. Gastroenterology. 1997;113:198391. DOIPubMedGoogle Scholar
  22. Valle  J, Kekki  M, Sipponen  P, Ihamäki  T, Siurala  M. Long-term course and consequences of Helicobacter pylori gastritis. Results of a 32-year follow-up study. Scand J Gastroenterol. 1996;31:54650. DOIPubMedGoogle Scholar
  23. Bonnevie  O. The incidence of duodenal ulcer in Copenhagen county. Scand J Gastroenterol. 1975;10:38593.PubMedGoogle Scholar
  24. Bonnevie  O. The incidence of gastric ulcer in Copenhagen county. Scand J Gastroenterol. 1975;10:2319.PubMedGoogle Scholar
  25. Cancer Statistics Review  SEER. 1973-1995, 1998. Available from: URL: http://www-seer.ims.nci.nih.gov/Publications/CSR7395.
  26. Karnes  WE, Samloff  IM, Siurala  M. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology. 1991;101:16774.PubMedGoogle Scholar
  27. American Cancer Society. Cancer facts and figures-- 1998. New York: The Society; 1998.
  28. Garfinkel  L. Cancer statistics and trends. In: Murphy GP, Lawrance W Jr, Lenhard RE Jr, editors. American Cancer Society textbook of clinical oncology. Atlanta: American Cancer Society; 1995. p. 1-9.
  29. Susser  M. Causes of peptic ulcer. A selective epidemiologic review. J Chronic Dis. 1967;20:43556. DOIPubMedGoogle Scholar
  30. Sonnenberg  A. Factors which influence the incidence and course of peptic ulcer. Scand J Gastroenterol Suppl. 1988;155:11940. DOIPubMedGoogle Scholar
  31. Sonnenberg  A. Geographic and temporal variations in the occurrence of peptic ulcer disease. Scand J Gastroenterol Suppl. 1985;110:1124. DOIPubMedGoogle Scholar
  32. Kuipers  EJ, Thijs  JC, Festen  HP. The prevalence of Helicobacter pylori in peptic ulcer disease. Aliment Pharmacol Ther. 1995;9(Suppl 2):5969.PubMedGoogle Scholar
  33. Olshansky  SJ, Carnes  BA. Ever since Gompertz. Demography. 1997;34:115. DOIPubMedGoogle Scholar
  34. Kurata  JH, Honda  GD, Frankl  H. The incidence of duodenal and gastric ulcers in a large health maintenance organization. Am J Public Health. 1985;75:6259. DOIPubMedGoogle Scholar
  35. Hoy  S. Chasing dirt. New York: Oxford University Press; 1995.
  36. Williams  JR, Nokes  DJ, Medley  GF, Anderson  RM. The transmission dynamics of hepatitis B in the UK: a mathematical model for evaluating costs and effectiveness of immunization programmes [published erratum appears in Epidemiol Infect 1996 Oct;117:409]. Epidemiol Infect. 1996;116:7189. DOIPubMedGoogle Scholar
  37. Porco  TC, Blower  SM. Quantifying the intrinsic transmission dynamics of tuberculosis. Theor Popul Biol. 1998;54:11732. DOIPubMedGoogle Scholar

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1Specific graphs can be made available to readers upon request.

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Page updated: December 16, 2010
Page reviewed: December 16, 2010
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