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Volume 7, Number 5—October 2001

Cost-Effectiveness of a Potential Vaccine for Coccidioides immitis

Amber E. Barnato*Comments to Author , Gillian D. Sanders†, and Douglas K. Owens†‡
Author affiliations: *University of Pittsburgh, Pittsburgh, Pennsylvania, USA; †Stanford University, Stanford, California, USA; ‡VA Palo Alto Health Care System, Palo Alto, California, USA

Main Article

Table 2

Health and economic outcomes of vaccination strategiesa

Age Strategyb Life expectancy (years; days) Incremental life expectancyc (days) Quality-adjusted life expectancy (years; days) Incremental quality-adjusted life expectancyc (days) Cost ($) Incremental costd ($) CE ratio ($/QALY)e
<17 No vaccine 28; 160.15 - 25; 172.98 - 35,196 - -
Screen/vaccinate 28; 160.58 0.43 25. 174.66 1.68 35,187 -9 -
Vaccinate 28; 160.62 0.04 25; 174.84 0.18 35,163 -24 Dominates
18-65 No vaccine 21; 272.68 - 18; 60.12 - 47,477 - -
Screen/vaccinate 21; 272.82 0.14 18; 60.65 0.53 47,568 90 62,000
Vaccinate 21; 272.84 0.02 18; 60.70 0.05 47,601 33 235,000

aLife expectancy and costs are discounted at 3% per year.
bStrategies are ranked by effectiveness, from the least to the most effective, for each age group.
cAll incremental values compare an alternative with the next most effective strategy (e.g., cost [screen/vaccinate] - cost [no vaccine] = incremental cost [screen/vaccinate over no vaccine]).
dNegative values reflect cost savings compared to the next most effective strategy.
eCost-effectiveness ratio: refer to Appendix for formula. A strategy dominates if it is both more effective and less expensive than all comparison strategies.
Screen/vaccinate = vaccination of susceptible persons identified through a screening skin test; vaccinate = vaccination of all persons.

Main Article

Page created: April 26, 2012
Page updated: April 26, 2012
Page reviewed: April 26, 2012
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