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Volume 7, Number 5—October 2001
Research

Clonal Expansion of Sequence Type (ST-)5 and Emergence of ST-7 in Serogroup A Meningococci, Africa

Pierre NicolasComments to Author , Laurent Décousset, Vincent Riglet, Philippe Castelli, Richard Stor, and Guy Blanchet
Author affiliations: Institut de Médecine Tropicale du Service de Santé des Armées, World Health Organization Collaborating Center, Marseille Armées, France

Main Article

Table

Characteristics of 104 serogroup A meningococci isolated in Africa, from 1988 to 1999a

Allele no.
Yr. Country No. meningitiscases No. of isolates Serogroup Type Subtype abcZ adk aroE fumC gdh pdhC pgm Sequence type (ST)
1988 Chad 7,867 3 A 4 P1.9 1 1 2 1 3 2 3 ST-5
1991 Djibouti 31 1 A 4 P1.9 1 1 2 1 3 2 3 ST-5
1992 Algeria 529 4 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Algeria 1 A 4 P1.10 1 3 1 1 1 1 3 ST-1
Burundi 2,739 4 A 4 P1.9 1 1 2 1 3 2 3 ST-5
CAR 1,226 3 A 4 P1.9 1 1 2 1 3 2 3 ST-5
1993 Cameroon 5,372 3 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Guinea Bissau 3 A 4 P1.9 1 1 2 1 3 2 3 ST-5
1994 Burundi 42 1 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Cameroon 578 2 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Chad 948 1 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Zaire 3 A 4 P1.9 1 1 2 1 3 2 3 ST-5
1995 Algeria 1 A 4 P1.9 1 1 2 1 3 2 19 ST-7
Cameroon 2 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Burk. Faso 2,595 1 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Burk. Faso 1 A 4 P1.9 2 1 2 1 3 2 3 ST-580
Niger 43,203 4 A 4 P1.9 1 1 2 1 3 2 3 ST-5
1996 Burk. Faso 42,129 2 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Cameroon 178 3 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Chad 1,079 1 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Niger 16,145 3 A 4 P1.9 1 1 2 1 3 2 3 ST-5
1997 Burk.Faso 22,305 1 A 4 P1.9 2 1 2 1 3 2 3 ST-580
Cameroon 572 2 A 4 P1.9 1 1 2 1 3 2 19 ST-7
Chad 1,123 1 A 4 P1.9 1 1 2 1 3 2 19 ST-7
Mali 11,228 2 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Niger 4,910 6 A 4 P1.9 1 1 2 1 3 2 3 ST-5
1998 Cameroon 2,887 1 A 4 P1.9 1 1 2 1 3 2 19 ST-7
Chad 7,964 2 A 4 P1.9 1 1 2 1 3 2 19 ST-7
Ivory Coast 3 2 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Niger 2,328 4 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Senegal 2,709 3 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Zaire 1,991 2 A 4 P1.9 1 1 2 1 3 2 19 ST-7
1999 Cameroon 2,272 2 A 4 P1.9 1 1 2 1 3 2 19 ST-7
Chad 2,540 2 A 4 P1.9 1 1 2 1 3 2 19 ST-7
Guinea 2,836 2 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Niger 5,576 7 A 4 P1.9 1 1 2 1 3 2 19 ST-7
Senegal 4,939 6 A 4 P1.9 1 1 2 1 3 2 3 ST-5
Senegal 1 A 4 P1.9 1 64 2 1 3 2 3 ST-581
Sudan 33,313 11 A 4 P1.9 1 1 2 1 3 2 19 ST-7

aMultilocus sequence typing showed the clonal expansion of ST-5 and emergence of ST-7, which was identified for the first time in Algeria in 1995; in Cameroon and Chad in 1997, 1998, and 1999; and in Zaire, Niger, and Sudan in 1999. Allele numbers and reference strains are registered at the MLST website (http://www.mlst.net).

Main Article

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