Volume 9, Number 11—November 2003
Research
Fluoroquinolones and the Risk for Methicillin-resistant Staphylococcus aureus in Hospitalized Patients1
Table 2
Results of multivariable analysisa
Risk factor |
MRSA cases |
MSSA cases |
|||
---|---|---|---|---|---|
OR (95% CI) |
p value |
OR (95% CI) |
p value |
||
Primary covariates | |||||
Levofloxacin |
3.38 (1.94 to 5.90) |
<0.001 |
0.69 (0.34 to 1.40) |
0.30 |
|
Ciprofloxacin |
2.48 (1.32 to 4.67) |
0.005 |
0.47 (0.21 to 1.02) |
0.06 |
|
Other covariates |
|||||
Lung disease |
3.94 (2.43to6.40) |
<0.001 |
2.33 (1.43 to 3.81) |
<0.001 |
|
Renal disease |
* |
1.98 (1.03 to 3.80) |
0.04 |
||
Penicillin |
* |
1.78 (0.93 to 3.39) |
0.08 |
||
Metronidazole |
1.92 (1.10 to 3.37) |
0.02 |
1.29 (0.65 to 2.56) |
0.46 |
|
ICU stay |
5.33 (3.28 to 8.68) |
<0.001 |
4.60 (2.90 to 7.30) |
<0.001 |
|
Emergent admission |
1.74 (1.09 to 2.78) |
0.02 |
1.90 (1.17 to 3.08) |
0.01 |
|
Admission service |
|||||
Medical |
* |
— |
— |
||
Obstetrical |
* |
0.29 (0.08 to 1.05) |
0.06 |
||
Surgical | * | 1.82 (1.12 to 2.97) | 0.02 |
aAll results adjusted for time at risk. Only variables significant (p < 0.05) on univariate analysis were included in final models. Several variables (indicated with an asterisk) met criteria for inclusion in the MSSA (methicillin-susceptible Staphylococcus aureus), but not the MRSA (methicillin-resistant Staphylococcus aureus) model. OR, odds ratio; CI, confidence interval; ICU, intensive care unit.
1This study was presented in part at the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Sand Diego, California, September 2002.
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