Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 21, Number 10—October 2015

Severe Sepsis Caused by California Serogroup Orthobunyavirus

Daniel K. RogstadComments to Author , Elizabeth Schiffman, David Neitzel, and Larry M. Baddour
Author affiliations: Loma Linda University, Loma Linda, California, USA (D.K. Rogstad); Mayo Clinic, Rochester, Minnesota, USA (D.K. Rogstad, L.M. Baddour); Minnesota Department of Health, St. Paul, Minnesota, USA (E. Schiffman, D. Neitzel)

Main Article


Pathogen testing in patient with undifferentiated severe sepsis, Minnesota, USA, 2014*

Pathogen tested Serum sample
Acute phase Convalescent phase
HIV-1/-2 Ag/Ab screen negative
Leptospira IgM/IgG negative
Cryptococcus Antigen screen negative
Anaplasma phagocytophilum IgG <1:64, PCR negative
Ehrlichia chaffeensis IgG <1:64, PCR negative
Ehrlichia ewingii/canis PCR negative
Ehrlichia muris–like PCR negative
Borrelia burgdorferi Ab screen negative Ab screen negative
Babesia microti IgG <1:64, PCR negative
Babesia duncani PCR negative
Babesia divergens strain MO-1 PCR negative
West Nile virus IgM/IgG and PCR negative IgM/IgG negative
Eastern equine encephalitis virus IgM/IgG <1:10 IgM/IgG <1:10
Western equine encephalitis virus IgM/IgG <1:10 IgM/IgG <1:10
St. Louis encephalitis virus IgM/IgG <1:10 IgM/IgG <1:10
California serogroup virus IgM ≥1:10,† IgG 1:10 IgM 1:80, IgG 1:320
Powassan/tick-borne encephalitis virus‡ IgM negative
La Crosse virus‡ IgM negative, PRNT <10 PRNT 320
Jamestown Canyon virus‡ IgM negative, PRNT 160 PRNT 10,240

*Positive control value for PRNT testing was >1,280. Ag, antigen; Ab, antibody, Ig, immunoglobulin, PRNT, plaque reduction neutralization testing.
†Additional dilution of result not performed.
‡Testing performed at the Arboviral Diseases Branch Laboratory, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.

Main Article

Page created: September 22, 2015
Page updated: September 22, 2015
Page reviewed: September 22, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.