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Volume 22, Number 12—December 2016
Research

Vertebrate Host Susceptibility to Heartland Virus

Angela M. Bosco-Lauth, Amanda E. Calvert, J. Jeffrey Root, Tom Gidlewski, Brian H. Bird, Richard A. Bowen, Atis Muehlenbachs, Sherif Zaki, and Aaron C. BraultComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (A.M. Bosco-Lauth, A.E. Calvert, A.C. Brault); Colorado State University; Fort Collins (A.M. Bosco-Lauth, R.A. Bowen); US Department of Agriculture, Fort Collins (J.J. Root, T. Gidlewski); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (B.H. Bird, A. Muehlenbachs, S.R. Zaki)

Main Article

Table 1

Experimental inoculation of vertebrate hosts with Heartland virus*

Experimental animal model Strain No. Age, d/sex Inoculum dose, PFU Route of inoculation
Mouse C57BL/6 15 21/ F 104 ip
Mouse Ag129 15 21/M and F 104 ip
Mouse Ag129 15 21/M and F 103 ip
Mouse Ag129 15 21/M and F 102 ip
Mouse Ag129 15 21/M and F 101 ip
Mouse Ag129 15 21/M and F 100 ip
Mouse† CD-1 10 2 103 ic
Mouse† CD-1 10 17 103 ip
Chicken Leghorn 3 Adult/F 104 sc
Hamster Syrian golden 5 21/F 104 sc
Goat Boer 2 Adult/M and F 104 sc
Rabbit New Zealand white 3 Adult/F 104 sc
Raccoon Wild-caught 6 Adult/M and F 104 sc

*Ag129, interferon-α/β/γ receptor–deficient; ic, intracranial; ip, intraperitoneal; sc, subcutaneous.
†CD-1 mice were also inoculated similarly with Lone Star virus (same dose and route as for Heartland virus).

Main Article

Page created: November 17, 2016
Page updated: November 17, 2016
Page reviewed: November 17, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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