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Volume 23, Number 11—November 2017

Airborne Transmission of Highly Pathogenic Influenza Virus during Processing of Infected Poultry

Kateri Bertran, Charles Balzli, Yong-Kuk Kwon1, Terrence M. Tumpey, Andrew Clark, and David E. SwayneComments to Author 
Author affiliations: US Department of Agriculture, Athens, Georgia, USA (K. Bertran, C. Balzli, Y.-K. Kwon, D.E. Swayne); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (T.M. Tumpey); International Veterinary Consultant, Pendleton, Oregon, USA (A. Clark)

Main Article

Table 2

Experimental design and clinical outcome of animal hosts exposed to airborne H5N1 HPAI viruses through simulated live-poultry market slaughter*

Virus Intranasally infected birds processed (no.) Duration of slaughter process, min Naive exposed hosts (no.)† Deaths of 
exposed hosts 
(mean time of death) Virus detection in exposed hosts‡ Seroconversion 
in surviving exposed hosts§
Mong/05 Chickens (10) 60 Chickens (5) 5/5 (4.4 dpe) 5/5 at time of death¶ NA
VN/04 Chickens (10) 60 Chickens (5) 5/5 (4.0 dpe) 5/5 at time of death¶ NA
VN/04 Chickens (10) 60 Ferrets (4) 3/4 (8.3 dpe) 1/4 on 3 dpe (3.0)¶ 0/1
VN/04 Ducks (5) 30 Ducks (5) 0/5 5/5 (1.6) 1/5
VN/04 Ducks (5) 30 Ferrets (3) 0/3 0/3 0/3

*dpe, days postexposure; EID, mean egg infectious dose; Mong/05, A/whooper swan/Mongolia/244/2005; NA, not available; VN/04, A/Vietnam/1203/2004.
†Exposed hosts placed 75–80 cm from the slaughter area.
‡No. positive/total no. Numbers in parentheses indicate mean virus titers (log10 EID50/mL) determined by virus isolation in embryonating chicken eggs from oral and cloacal swab samples of exposed poultry or by nasal wash samples of exposed ferrets.
§Determined by hemagglutinin inhibition and virus neutralization tests when >12 dpe serum samples were available.
¶Virus antigen was detected by immunohistochemistry in tissues of 5/5 Mong/05-exposed chickens, 5/5 VN/04-exposed chickens, and 3/4 VN/04-exposed ferrets.

Main Article

1Current affiliation: Animal and Plant Quarantine Agency, Gimcheon-si, South Korea.

Page created: October 26, 2017
Page updated: October 26, 2017
Page reviewed: October 26, 2017
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