Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 1—January 2018
Research

Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China

Vincent C.C. Cheng1, Siddharth Sridhar1, Shuk-Ching Wong, Sally C.Y. Wong, Jasper F.W. Chan, Cyril C.Y. Yip, Chi-Hung Chau, Timmy W.K. Au, Yu-Yan Hwang, Carol S.W. Yau, Janice Y.C. Lo, Cheuk-Kwong Lee, and Kwok-Yung YuenComments to Author 
Author affiliations: University of Hong Kong, Hong Kong (V.C.C. Cheng, S. Sridhar, S.C.Y. Wong, J.F.W. Chan, C.C.Y. Yip, K.-Y. Yuen); Queen Mary Hospital, Hong Kong (V.C.C. Cheng, S.-C. Wong, T.W.K. Au, Y.-Y. Hwang); Grantham Hospital, Hong Kong (C.-H. Chau); Centre for Health Protection, Hong Kong (C.S.W. Yau, J.Y.C. Lo); Hong Kong Red Cross Blood Transfusion Service, Hong Kong (C.-K. Lee)

Main Article

Table

Demographics, investigation results, and clinical details of asymptomatic JEV-infected blood donor and recipients, Hong Kong, China, May‒July 2017*

Variable Donor Packed red blood cell recipient (index patient) Platelet recipient Plasma recipient
Underlying disease
 No history of disease, no recent travel to JEV-endemic regions outside Hong Kong; resides in JEV-endemic area Tin Shui Wai, Yuen Long
 End-stage chronic obstructive pulmonary disease with lung transplantation, May 10
 Acute myeloid leukemia post induction chemotherapy with cytarabine and daunorubicin
 Intracranial hemorrhage
Blood donation or transfusion type, date
 Blood donation, May 29
Packed red blood cell transfusion, June 22
 Platelet transfusion, June 2
 Plasma transfusion, June 20
Pretransfusion IgM serology result, date
 Specimen not available
 Serum negative, May 31
 Serum negative, May 25
 Specimen not available
Posttransfusion IgM serology result, date
 Serum positive, July 22
 CSF positive, July 11; serum positive, July 15 and 18
 Serum positive, July 5 and 22
 Specimen not available
JEV nucleic acid test, specimen type and result, date
 Positive archived blood specimen
 Positive blood sample, June 26 and 28; positive bronchoalveolar lavage, July 10
 Negative plasma sample, July 22; negative urine sample, July 25
 Specimen not available
Clinical symptoms
 Asymptomatic
 Fever and rash July 6 (14 d after transfusion), followed by decreased consciousness and myoclonic jerks; MRI showed typical appearance of T2 hyperintensity of bilateral thalami, substantia nigra, and medial temporal lobes
 Asymptomatic
 Unknown
Outcome Full recovery Died October 1, 2017 Full recovery Died from respiratory failure 14 d after transfusion

*CSF, cerebrospinal fluid; JEV, Japanese encephalitis virus; MRI, magnetic resonance imaging.

Main Article

1These authors contributed equally to this article.

Page created: December 19, 2017
Page updated: December 19, 2017
Page reviewed: December 19, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external