Substance Use and Adherence to HIV Preexposure Prophylaxis for Men Who Have Sex with Men1
, Sonia Jain, David Moore, Deborah Collins, Xiaoying Sun, Peter L. Anderson, Katya Corado, Jill S. Blumenthal, Eric S. Daar, Joel Milam, Michael P. Dubé, Sheldon Morris, and for the California Collaborative Treatment Group 595 Team
Author affiliations: Medical University of Graz, Graz, Austria (M. Hoenigl); University of California, San Diego, California, USA (M. Hoenigl, S. Jain, D. Moore, X. Sun, J.S. Blumenthal, S. Morris); Department of Health and Human Services, Long Beach, California, USA (D. Collins); University of Anschutz Medical Campus, Aurora, Colorado, USA (P.L. Anderson); Harbor UCLA Medical Center, Torrance, California, USA (K. Corado, E.S. Daar); University of Southern California Keck School of Medicine, Los Angeles, California, USA (J. Milam, M.P. Dubé)
Figure 2. Substance use and adherence to HIV preexposure prophylaxis among transgender women and men who have sex with men, California, USA. A, B) Boxplots showing dried blood spot TFV-DP levels at weeks 12 (A) and 48 (B) for persons with no, some, and frequent ongoing substance use. C, D) Boxplots showing dried blood spot TFV-DP levels at week 48 in persons with and without alcohol (C) and substance use (D) problems, according to assessments with AUDIT (C) and DAST (D) (cross-sectional analysis). In each case, dried blood spot TFV-DP levels were compared among the 3 groups by using the analysis of variance test. Circles indicate outliers; horizontal lines within boxes indicate medians, box bottoms and tops indicate 25th and 75th quartiles; and error bars indicate levels within 1.5 times the interquartile range of the lower quartile and upper quartiles. AUDIT, Alcohol Use Disorders Identification Test; DAST, Drug Abuse Screening Test; TFV-DP, tenofovir diphosphate.
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