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Volume 25, Number 4—April 2019

Enterovirus A71 Phenotypes Causing Hand, Foot and Mouth Disease, Vietnam

Hoang Minh Tu VanComments to Author , Nguyen To Anh, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Lam Anh Nguyet, Tran Tan Thanh, Nguyen Thi Han Ny, Vu Thi Ty Hang, Truong Huu Khanh, Ho Lu Viet, Do Chau Viet, Ha Manh Tuan, Nguyen Thanh Hung, Du Tuan Quy, Do Quang Ha, Phan Tu Qui, Le Nguyen Thanh Nhan, Guy Thwaites, Nguyen Van Vinh Chau, Louise Thwaites, H. Rogier van Doorn, and Le Van TanComments to Author 
Author affiliations: Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam (H.M.T. Van, N.T. Anh, N.T.T. Hong, L.N.T. Nhu, L.A. Nguyet, T.T. Thanh, N.T.H. Ny, V.T.T. Hang, D.Q. Ha, G. Thwaites, L. Thwaites, H.R. van Doorn, L.V. Tan); Children’s Hospital 2, Ho Chi Minh City (H.M.T. Van, H.L. Viet, D.C. Viet, H.M. Tuan); Children’s Hospital 1, Ho Chi Minh City (T.H. Khanh, N.T. Hung, D.T. Quy, L.N.T. Nhan); University of Oxford, Oxford, UK (P.T. Qui, G. Thwaites, L. Thwaites, H.R. van Doorn); Hospital for Tropical Diseases, Ho Chi Minh City (N.V.V. Chau)

Main Article

Table 1

Demographics and clinical severities of enterovirus A71 in patients with hand, foot and mouth disease, Vietnam, July 2013–July 2015*

Characteristic Total EV-A71 cases enrolled, n = 379 EV-A71 cases included for phylogenetic analysis, n = 146 Subgenogroup C4 cases, n = 10 Subgenogroup B5 cases, n = 136
M 213 (56.2) 89 (61) 8 (80) 81 (59.6)
166 (43.8)
57 (39)
2 (20)
55 (40.4)
Median age, mo (range)
21.9 (14.3–32.1)
19.4 (13.2–30.8)
13.9 (15.5–23.5)
19.6 (13–31.2)
Discharge grade†
  1 168 (44.3) 78 (53.4) 0 78 (57.4)
  2a 120 (31.7) 42 (28.8) 3 (30) 39 (28.7)
  2b1 30 (7.9) 13 (8.9) 4 (40) 9 (6.6)
  2b2 16 (4.2) 10 (6.8) 2 (20) 8 (5.9)
  3 43 (11.3) 3 (2.1) 1 (10) 2 (1.5)
2 (0.5)
Death 0 0 0 0

*Values are no. (%) except as indicated. EV-A71, enterovirus A71.
†Grade 1, mouth ulcers or vesicles or papules on hands, feet, or buttocks, with or without mild fever (temperature <39°C). Grade 2a, central nervous system involvement, (myoclonus reported by parents or caregivers only, temperature >39°C or ataxia). Grade 2b1, myoclonus observed by medical staff or history of myoclonus and lethargy or pulse >130 bpm. Grade 2b2, ataxia, nystagmus, limb weakness, cranial nerve palsies, persistent high fever, or pulse >150 bpm. Grade 3, autonomic dysfunction with sweating, hypertension, tachycardia, and tachypnea. Grade 4, additional cardiopulmonary compromise with pulmonary edema or shock syndrome.

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Page created: March 18, 2019
Page updated: March 18, 2019
Page reviewed: March 18, 2019
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