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Volume 25, Number 5—May 2019
Research Letter

Hepatic Brucelloma Diagnosis and Long-Term Treatment, France

Marie AmsilliComments to Author , Olivier Epaulard, Jean-Paul Brion, Patricia Pavese, Christian Letoublon, Isabelle Pelloux, and Max Maurin
Author affiliations: Centre Hospitalier Universitaire de Grenoble, Grenoble, France (M. Amsilli, O. Epaulard, J.-P. Brion, P. Pavese, C. Letoublon, I. Pelloux, M. Maurin); Université Grenoble Alpes, Grenoble (O. Epaulard, C. Letoublon, M. Maurin)

Main Article


Diagnostic and blood tests on patient with hepatic brucellosis, Grenoble, France

Test Reference value 2015 Apr 2015 Nov 2016 Jan
Rose Bengal plate agglutination test (bioMérieux, NA Strongly positive Positive Negative
Tube agglutination test (Elitech, >80 160 20 <20
Immunofluorescence IgM (BioRad, >40 <20 <20 <20
Immunofluorescence IgG (BioRad) >80 160 160 320
Brucella PCR testing of liver tissue biopsies NA Positive for 16S rDNA NA Positive for bcsp31 gene
Blood cultures NA Negative Negative Negative
Liver abscess and tissue cultures† (bacteria, fungi and mycobacteria) NA Negative NA Negative
C-reactive protein, mg/L <3 56 5 4
Fibrinogen, g/L 2.1–4.1 6.1
Leukocyte count, G/L 4–11 8.5 5 4.9
Neutrophil count, G/L 1.6–8.8 5.9 2.5 2.1
Thrombocyte count, G/L 150–400 489 287 284
Bilirubin, µmol/L 3–17 5 5 5
Alkaline phosphatase, IU/L 50–136 158 85 69
γ-glutamyl transferase, IU/L 5–55 107 31 23
Aspartate aminotransferase, IU/L 15–37 20 16 14
Alanine aminotransferase, IU/L
*NA, not applicable. 
†Tissues were cultured for bacteria, fungi, and mycobacteria.

Main Article

Page created: April 17, 2019
Page updated: April 17, 2019
Page reviewed: April 17, 2019
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