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Volume 25, Number 6—June 2019
Research

Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015

Yeon-Sook Kim1, Abdimadiyeva Aigerim1, Uni Park1, Yuri Kim, Ji-Young Rhee, Jae-Phil Choi, Wan Beom Park, Sang Won Park, Yeonjae Kim, Dong-Gyun Lim, Kyung-Soo Inn, Eung-Soo Hwang, Myung-Sik Choi, and Nam-Hyuk Cho2Comments to Author 
Author affiliations: Chungnam National University School of Medicine, Daejeon, South Korea (Y.-S. Kim); Seoul National University College of Medicine, Seoul, South Korea (A. Aigerim, U. Park, Y. Kim, W.B. Park, S.W. Park, E.-S. Hwang, M.-S. Choi, N.-H. Cho); Dankook University College of Medicine, Cheonan, South Korea (J.-Y. Rhee); Seoul Medical Center, Seoul (J.-P. Choi); National Medical Center, Seoul (Y. Kim, D.-G. Lim, H.S. Shin); Kyung Hee University, Seoul (K.-S. Inn); Seoul National University Medical Research Center and Bundang Hospital, Seoul (N.H. Cho)

Main Article

Figure 3

Increased resistance of Middle East respiratory syndrome coronavirus (MERS-CoV) against antibody-mediated neutralization by spike mutations during the 2015 outbreak in South Korea. A) Neutralizing activity of serum samples against lentiviruses bearing WT and mutant spikes. 50% pseudoparticle neutralization test titers against lentiviruses bearing WT or mutant spikes (I529T or D510G) in serum samples from mice (n = 6) immunized with WT spike antigen are plotted. Mean values are indicated by red l

Figure 3. Increased resistance of Middle East respiratory syndrome coronavirus (MERS-CoV) against antibody-mediated neutralization by spike mutations during the 2015 outbreak in South Korea. A) Neutralizing activity of serum samples against lentiviruses bearing WT and mutant spikes. 50% pseudoparticle neutralization test titers against lentiviruses bearing WT or mutant spikes (I529T or D510G) in serum samples from mice (n = 6) immunized with WT spike antigen are plotted. Mean values are indicated by red lines. Statistical significance was calculated by using analysis of variance with Newman–Keuls post t-test correction. *p<0.05. B) Neutralization activity against MERS-CoV bearing WT or I529T mutant spike mutation in serum samples from 3 recovered patients (P002, P009, and P010) who carried only WT MERS-CoV. ppNT50, 50% pseudoparticle neutralization test; PRNT50, 50% plaque reduction neutralization test; WT, wild-type.

Main Article

1These first authors contributed equally to this article.

2These authors were co-principal investigators.

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Page updated: May 20, 2019
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