Volume 26, Number 11—November 2020
Research
Validated Methods for Removing Select Agent Samples from Biosafety Level 3 Laboratories
Table 1
Maximum bacterial concentrations of select agents in tissues of infected mice*
Agent (reference) | Source of samples, bacterial load |
|||
---|---|---|---|---|
Lung, per g | Cell pellet, per mL BAL | Blood, per mL | Overnight culture, per mL | |
Bacillus anthracis (5,6) | <108 | Not tested | <104 | 108 |
Yersinia pestis (7) | <1010 | Not tested | <106 | 109 |
Burkholderia mallei (8–11) | <109† | Not tested | <104 | 109 |
Burkholderia pesudomallei (11,12) | <108 | 105‡ | <105 | 109 |
Francisella tularensis (13) | 107 | Not tested | <105 | 109 |
References
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- Centers for Disease Control and Prevention; Animal and Plant Health Inspection Service. Guidance on the Inactivation or Removal of Select Agents or Toxins for Future Use. 2018 [cited 2019 Aug 4]. https://www.selectagents.gov/irg-intro.html
- US Government Accountability Office. Actions Needed to Improve Management of DOD's Biosafety and Biosecurity Program. 2018 [cited 2019 Aug 4]. https://www.gao.gov/products/GAO-18-422
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