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Volume 26, Number 12—December 2020
Online Report

Role of Oral Rabies Vaccines in the Elimination of Dog-Mediated Human Rabies Deaths

Ryan M. WallaceComments to Author , Florence Cliquet, Christine Fehlner-Gardiner, Anthony R. Fooks, Claude T. Sabeta, Alvaro Aguilar Setién, Changchun Tu, Vlad Vuta, Boris Yakobson, Dong-Kun Yang, Gideon Brückner, Conrad M. Freuling, Lea Knopf, Artem Metlin, Patricia Pozzetti, Pebi Purwo Suseno, Sean V. Shadomy, Gregorio Torres, Marco Antonio Natal Vigilato, Bernadette Abela-Ridder, and Thomas Müller
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (R.M. Wallace, S.V. Shadomy); Agency for Food, Environmental, and Occupational Health and Safety, Malzéville, France (F. Cliquet); Canadian Food Inspection Agency, Ottawa, Ontario, Canada (C. Fehlner-Gardiner); Animal and Plant Health Agency, Weybridge, UK (A.R. Fooks); Onderstepoort Veterinary Institute, Pretoria, South Africa (C.T. Sabeta); Unidad de Investigación Médica en Inmunología, Coordinación de Investigación en Salud, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico (A.A. Setién); Academy of Agricultural Sciences, Changchun, China (C. Tu); Institute for Diagnosis and Animal Health, Faculty of Veterinary Medicine, Bucharest, Romania (V. Vuta); Kimron Veterinary Institute, Beit Dagan, Israel (B. Yakobson); Animal and Plant Quarantine Agency, Gimcheong-si, South Korea (D.-K. Yang); World Organisation for Animal Health, Paris, France (G. Brückner, P. Pozzetti, G. Torres); Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany (C.M. Freuling, T. Müller); World Health Organization, Geneva, Switzerland (L. Knopf, B. Abela-Ridder); Federal Centre for Animal Health, Vladimir, Russia (A. Metlin); Ministry of Agriculture, Jakarta, Indonesia (P. Purwo Suseno); Food and Agriculture Organization of the United Nations, Rome, Italy (S.V. Shadomy); Pan American Health Organization, Rio de Janeiro, Brazil (M.A.N. Vigilato)

Main Article

Table 3

Landscape analysis of potential oral rabies vaccine candidates

Vaccine name Manufacturer Construct Review status* Licensure status
V-RG
 Boehringer Ingelheim, Germany
 Recombinant vaccinia virus
 Safe and efficacious
 Licensed for wildlife in Europe and USA
ONRAB
 Artemis, Canada
 Recombinant adenovirus
 Safe and efficacious
 Licensed for wildlife in Canada
SPBN GASGAS
 Ceva, France
 Recombinant rabies virus
 Safe and efficacious
 Licensed for wildlife in Europe
ERA G333
 Prokov, Russia
 Recombinant rabies virus
 Not assessed
 Licensed for wildlife in Russia
SAG2
 VIRBAC, France
 Attenuated rabies virus
 Safe and efficacious
 Licensed for wildlife in Europe
SAD B19
 Ceva, France
 Attenuated rabies virus
 Low residual pathogenicity
 Licensed for wildlife in Europe
SAD Bern
 Bioveta, Czech Republic
 Attenuated rabies virus
 Low residual pathogenicity
 Licensed for wildlife in Europe
SAD Clone
 Bioveta, Czech Republic
 Attenuated rabies virus
 Low residual pathogenicity
 Licensed for wildlife in Europe
RV-97
 FGBI ARRAIH, Russia
 Attenuated rabies virus
 Low residual pathogenicity
 Licensed for wildlife in Russia
KMIEV-94
 Institute of Experimental Veterinary, Belarus
 Attenuated rabies virus
 Not assessed
 Licensed for wildlife in Belarus
VRC-RZ2 Kazakhstan Attenuated rabies virus Not assessed Licensed for wildlife in Kazakhstan

*Review status refers to safety and efficacy in the target species based on published data.

Main Article

Page created: October 15, 2020
Page updated: November 19, 2020
Page reviewed: November 19, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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