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Volume 26, Number 8—August 2020
CME ACTIVITY - Research

Sporadic Creutzfeldt-Jakob Disease among Physicians, Germany, 1993–2018

Peter Hermann1Comments to Author , Johannes Treig1, Steffen Unkel, Stefan Goebel, Timothy Bunck, Martha Jünemann, Tim Friede, and Inga Zerr
Author affiliations: University Medical Center Göttingen Department of Neurology, Göttingen, Germany (P. Hermann, J. Treig, S. Goebel, T. Bunck, M. Jünemann, I. Zerr); University Medical Center Göttingen Department of Medical Statistics, Göttingen (S. Unkel, T. Friede); German Center for Neurodegenerative Diseases, Göttingen (I. Zerr)

Main Article

Table 1

Characteristics of sCJD patients, Germany, 1993–2018*

Variable Cohort A Cohort B Validation cohort
Time period
1993 Jun–2005 Dec
2006 Jan–2016 Dec
2017 Jan–2018 Dec
Total, no. (%) 1,250 (100) 1,491 (100) 234 (100)
Definite sCJD 711 (57) 491 (33) 59 (25)
Probable sCJD
539 (43)
1,000 (67)
175 (75)
Mean age, y (range)
66 (35–90)
68 (37–93)
68 (41–91)
Sex
F 731 (58) 769 (52) 118 (50)
M
519 (42)
722 (48)
116 (50)
Codon 129, no. (%)
MM 693 (67) 322 (55) 8 (53)†
MV 180 (17) 134 (23) 7 (47)†
VV
166 (16)
125 (22)
0
Occupation known, no. (%)
1,093 (87)
439 (29)
70 (30)
Physicians, no. (% of all patients, % of known occupation) 4 (0.3, 0.4) 13 (0.9, 3) 5 (2.1, 7.1)

*MM, methionine homzygosity; MV, heterozygosity; sCJD, sporadic Creutzfeldt-Jakob disease; VV, valin homozygosity.
†Since 2015, codon 129 analyses were not regularly performed during neuropathologic investigation.

Main Article

1These authors contributed equally to this article.

Page created: April 27, 2020
Page updated: July 15, 2020
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