Volume 27, Number 1—January 2021
Research
Comparative Omics Analysis of Historic and Recent Isolates of Bordetella pertussis and Effects of Genome Rearrangements on Evolution
Ana Dienstbier, Fabian Amman, Denisa Petráčková, Daniel Štipl, Jan Čapek, Jana Zavadilová, Kateřina Fabiánová, Jakub Držmíšek, Dilip Kumar, Mark Wildung, Derek Pouchnik, and Branislav Večerek
Table 3
Genes expressing consistently increased RNA and protein levels in isolates of Bordetella pertussis and 9 infected patients, Czech Republic, compared with Tohama I*
| Gene in Tohama I | Gene group | Gene name | Transcriptome |
Proteome |
Secretome |
Annotation | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cz/Toh | VS/Toh | Cz/Toh | VS/Toh | Cz/Toh | VS/Toh | ||||||
| toh_00485 | Group_1902 | BP0500 | 2.1 | 2.8 | 1.5 | 1.3 | 6.0 | 5.1 | T3SS effector BopC | ||
| toh_00936 | Sbp | BP0966 | 14.7 | 13.0 | 5.6 | 4.6 | ND | ND | Sulfate-binding protein | ||
| toh_02200 | bscI | BP2249 | 2.1 | 3.1 | 1.2 | ND | 2.8 | 6.2 | T3SS protein BscI | ||
| toh_02203 | bopB | BP2252 | 2.1 | 3.0 | 3.1 | 2.8 | 2.1 | 1.8 | T3SS protein BopB | ||
| toh_02204 | bopD | BP2253 | 1.8 | 2.5 | 2.0 | 1.5 | 3.7 | 2.3 | T3SS protein BopD | ||
| toh_02205 | bcrH1 | BP2254 | 2.3 | 4.0 | 2.5 | 2.1 | 1.6 | 3.1 | T3SS protein | ||
| toh_02206 | Group_1710 | BP2255 | 2.4 | 3.8 | 3.9 | 4.0 | 4.8 | 1.7 | Hypothetical protein | ||
| toh_02207 | bsp22 | BP2256 | 2.4 | 3.6 | 1.6 | 1.5 | 3.6 | 1.8 | T3SS protein Bsp22 | ||
| toh_02208 | bopN | BP2257 | 2.5 | 2.9 | 1.3 | 1.0 | 3.1 | 1.5 | T3SS protein BopN | ||
| toh_02210 | Group_2630 | BP2259 | 2.0 | 2.4 | 1.4 | 1.9 | 5.1 | 2.4 | Putative T3SS protein | ||
| toh_02214 | bscE | BP2263 | 2.3 | 1.5 | 5.2 | 4.5 | 2.0 | 2.3 | T3SS protein BscE | ||
| toh_03375 | Group_1130 | BP3434 | 6.1 | 4.4 | 3.3 | 1.9 | 2.6 | 1.8 | Exported protein | ||
*Fold change values resulting from comparison of either recent isolates (Cz) or historic strains (VS) with Tohama I strain (Toh) are shown for RNA sequencing and proteomic analyses. Values that did not indicate statistical significance (FC>2; adjusted p<0.05) are shown in bold. ND, not determined; toh, Tohama.
Page created: September 01, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.