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Volume 27, Number 11—November 2021
Dispatch

Multinational Observational Cohort Study of COVID-19–Associated Pulmonary Aspergillosis1

Nico A.F. Janssen, Rémy Nyga, Lore Vanderbeke, Cato Jacobs, Mehmet Ergün, Jochem B. Buil, Karin van Dijk, Josje Altenburg, Catherine S.C. Bouman, Hans I. van der Spoel, Bart J.A. Rijnders, Albert Dunbar, Jeroen A. Schouten, Katrien Lagrou, Marc Bourgeois, Marijke Reynders, Niels van Regenmortel, Lynn Rutsaert, Piet Lormans, Simon Feys, Yves Debavaye, Fabienne Tamion, Damien Costa, Julien Maizel, Hervé Dupont, Taieb Chouaki, Saad Nseir, Boualem Sendid, Roger J.M. Brüggemann, Frank L. van de Veerdonk, Joost Wauters2, and Paul E. Verweij2Comments to Author 
Author affiliations: Radboud University Medical Center, Nijmegen, the Netherlands (N.A.F Janssen, M. Ergün, J.B. Buil, J.A. Schouten, R.J.M. Brüggemann, F.L. van de Veerdonk, P.E. Verweij); Amiens University Hospital, Amiens, France (R. Nyga, J. Maizel, H. Dupont, T. Chouaki); University Hospitals Leuven, Leuven, Belgium (L. Vanderbeke, C. Jacobs, K. Lagrou, Y. Debavaye, J. Wauters); Katholieke Universiteit Leuven, Leuven (L. Vanderbeke, K. Lagrou, J. Wauters); Amsterdam University Medical Centers, Amsterdam, the Netherlands (K. van Dijk, J. Altenburg, C.S.C. Bouman, H. van der Spoel); Erasmus Medical Center, Rotterdam, the Netherlands (B.J.A. Rijnders, A. Dunbar); AZ Sint-Jan Brugge-Oostende, Brugge, Belgium (M. Bourgeois, M. Reynders); ZNA Campus Stuivenberg, Antwerpen, Belgium (N. van Regenmortel, L. Rutsaert); AZ Delta Hospital, Roeselare, Belgium (P. Lormans, S. Feys); Rouen University Hospital, Rouen, France (F. Tamion, D. Costa); Lille University Hospital, Lille, France (S. Nseir, B. Sendid); University of Lille, Lille (S. Nseir, B. Sendid)

Main Article

Figure 2

Kaplan-Meier survival curves comparing patients with CAPA and those classified as CAPA excluded in a multinational observational study. A) Discovery cohort; B) validation cohort. Survival analysis performed by using Mantel-Cox log rank test. Survival over time differs significantly in the discovery cohort (n = 279); median estimated survival in the CAPA group is 42.0 days (p = 0.015 by log rank test). In the validation cohort (n = 209), survival over time is not significantly different between the 2 groups (p = 0.065 by log rank test). CAPA, COVID-19–associated pulmonary aspergillosis; COVID-19, coronavirus disease; ICU, intensive care unit.

Figure 2. Kaplan-Meier survival curves comparing patients with CAPA and those classified as CAPA excluded in a multinational observational study. A) Discovery cohort; B) validation cohort. Survival analysis performed by using Mantel-Cox log rank test. Survival over time differs significantly in the discovery cohort (n = 279); median estimated survival in the CAPA group is 42.0 days (p = 0.015 by log rank test). In the validation cohort (n = 209), survival over time is not significantly different between the 2 groups (p = 0.065 by log rank test). CAPA, COVID-19–associated pulmonary aspergillosis; COVID-19, coronavirus disease; ICU, intensive care unit.

Main Article

1The results of this study were presented at the Scientific Spring Meeting of the Dutch Society of Medical Microbiology (NVMM) and the Royal Dutch Society of Microbiology (KNVM), held online March 30–31, 2021; and at the 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), held online from July 9–12, 2021.

2These authors were co–principal investigators.

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Page updated: October 19, 2021
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