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Volume 27, Number 5—May 2021
Research

Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

Natalia Fintelman-Rodrigues, Aline P.D. da Silva, Monique Cristina dos Santos, Felipe B. Saraiva, Marcelo A. Ferreira, João Gesto, Danielle A.S. Rodrigues, André M. Vale, Isaclaudia G. de Azevedo, Vinícius C. Soares, Hui Jiang, Hongdong Tan, Diogo A. Tschoeke, Carolina Q. Sacramento, Fernando A. Bozza, Carlos M. Morel, Patrícia T. Bozza, and Thiago Moreno L. SouzaComments to Author 
Author affiliations: Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil (N. Fintelman-Rodrigues, A.P.D. da Silva, M.C. dos Santos, F.B. Saraiva, M.A. Ferreira, J. Gesto, I.G. de Azevedo, V.C. Soares, C.Q. Sacramento, F.A. Bozza, C.M. Morel, P.T. Bozza, T.M.L. Souza); Universidade Federal do Rio de Janeiro, Rio de Janeiro (D.A.S. Rodrigues, A.M. Vale, V.C. Soares, D.A. Tschoeke); MGI Tech Co., Ltd., Shenzhen, China (H. Jiang, H. Tan); D’Or Institute for Research and Education (F.A. Bozza)

Main Article

Figure 1

Heatmap showing the profile of innate immune response from patients who experienced 2 episodes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, Brazil, 2020. We measured the mediators of innate immunity by ELISA for patients A–D. For comparison, these molecules were also quantified in the plasma from 5 healthy donors negative for SARS-CoV-2. The heatmap displays the log2 ratio of the fold-change from the plasma of the patients over the healthy volunteers. The means + standard error of the means for the healthy volunteers were the following: IFN-α = 20.4 + 4.7 pg/mL; IFN-β = 26.0 + 3.9 pg/mL; IFN-γ = 27.8 + 7.8 pg/mL; IL-6 = 13.4 + 1.7 pg/mL; IL-8 = 137 + 21.6 pg/mL; IL-10 = 165.4 + 40.7 pg/mL; TNF-α = 33.8 + 11.5 pg/mL; and CXCL-10 = 61.0 + 27.3 pg/mL. CXCL, C-X-C motif chemokine ligand IFN, interferon; IL, interleukin; TNF, tumor necrosis factor.

Figure 1. Heatmap showing the profile of innate immune response from patients who experienced 2 episodes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, Brazil, 2020. We measured the mediators of innate immunity by ELISA for patients A–D. For comparison, these molecules were also quantified in the plasma from 5 healthy donors negative for SARS-CoV-2. The heatmap displays the log2 ratio of the fold-change from the plasma of the patients over the healthy volunteers. The means + standard error of the means for the healthy volunteers were the following: IFN-α = 20.4 + 4.7 pg/mL; IFN-β = 26.0 + 3.9 pg/mL; IFN-γ = 27.8 + 7.8 pg/mL; IL-6 = 13.4 + 1.7 pg/mL; IL-8 = 137 + 21.6 pg/mL; IL-10 = 165.4 + 40.7 pg/mL; TNF-α = 33.8 + 11.5 pg/mL; and CXCL-10 = 61.0 + 27.3 pg/mL. CXCL, C-X-C motif chemokine ligand IFN, interferon; IL, interleukin; TNF, tumor necrosis factor.

Main Article

Page created: April 01, 2021
Page updated: April 20, 2021
Page reviewed: April 20, 2021
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