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Volume 27, Number 5—May 2021
Research

Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

Natalia Fintelman-Rodrigues, Aline P.D. da Silva, Monique Cristina dos Santos, Felipe B. Saraiva, Marcelo A. Ferreira, João Gesto, Danielle A.S. Rodrigues, André M. Vale, Isaclaudia G. de Azevedo, Vinícius C. Soares, Hui Jiang, Hongdong Tan, Diogo A. Tschoeke, Carolina Q. Sacramento, Fernando A. Bozza, Carlos M. Morel, Patrícia T. Bozza, and Thiago Moreno L. SouzaComments to Author 
Author affiliations: Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil (N. Fintelman-Rodrigues, A.P.D. da Silva, M.C. dos Santos, F.B. Saraiva, M.A. Ferreira, J. Gesto, I.G. de Azevedo, V.C. Soares, C.Q. Sacramento, F.A. Bozza, C.M. Morel, P.T. Bozza, T.M.L. Souza); Universidade Federal do Rio de Janeiro, Rio de Janeiro (D.A.S. Rodrigues, A.M. Vale, V.C. Soares, D.A. Tschoeke); MGI Tech Co., Ltd., Shenzhen, China (H. Jiang, H. Tan); D’Or Institute for Research and Education (F.A. Bozza)

Main Article

Table

Characteristics of patients reinfected with severe acute respiratory syndrome coronavirus 2, Brazil, 2020*

Characteristic Patient A Patient B Patient C Patient D
Primo-infection
Sex M F M F
Age, y 54 57 34 34
Concurrent conditions None Discoid lupus erythematosus None None
Date of symptom onset March 21 March 26 Asymptomatic March 31
Symptoms Headache Mild diarrhea No Mild diarrhea
N1 RT-PCR, log10 copies/mL 5.12 3.21 3.83 3.01
Date conducted March 23 March 24 March 24 April 2
RNP RT-PCR (internal control), Ct 26.5 26.66 27.41 28.48
Serology† IgM, IgA, IgG detected IgM, IgA, IgG detected IgM, IgA, IgG detected IgM, IgA, IgG detected
PRNT90/25 uL† <1:4 <1:4 <1:4 <1:4
Sequencing Not enough sample Emerging clade 19A Emerging clade 20B Not enough sample
ID
N/A
EPI_ISL_636834
EPI_ISL_636836
NA
Second infection
Date of onset illness May 25 May 26 May 27 May 30
Symptoms Fever, dry cough, tiredness, body ache, anosmia, ageusia Fever, diarrhea, headache, body ache, anosmia, ageusia Fever, nausea, tiredness, headache, body ache Dry cough, diarrhea, tiredness, headache, body ache, anosmia, ageusia
RT-PCR, log10 copies/mL 7.31 7.42 5.18 9.61
Date conducted May 29 May 29 May 29 May 29
RNP RT-PCR internal control 24.6 27.06 28.12 24.5
Serology results‡ IgM, IgA, IgG detected IgM, IgA, IgG detected IgM, IgA, IgG undetectable IgM, IgA, IgG undetectable
PRNT90/25 uL‡ 1:16 <1:4 <1:4 <1:4
Sequencing Emerging clade 20B Emerging clade 20B Emerging clade 20B Emerging clade 20B
Accession ID
EPI_ISL_636737
EPI_ISL_636835
EPI_ISL_636837
EPI_ISL_636838
Follow-up
Serology§ IgM, IgA, IgG detected IgM, IgA, IgG detected IgM, IgA, IgG detected IgM, IgA, IgG detected
PRNT90/25 uL§ 1:128 1:32 1:64 1:64
Serology results¶ IgM, IgA, IgG detected IgM, IgA, IgG detected IgM, IgA, IgG detected IgM, IgA, IgG detected
PRNT90/25 uL 1:64 1:16 1:8 1:8

*N1, nucleocapside gene; NA, not available; PRNT90, 90% plaque-reduction neutralization test; RNP, human RNase P gene; RT-PCR, reverse transcription PCR. 
†Tests conducted March 27.
‡Tests conducted June 3. 
§Tests conducted July 9.
¶Tests conducted August 10.

Main Article

Page created: April 01, 2021
Page updated: April 20, 2021
Page reviewed: April 20, 2021
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