Volume 27, Number 7—July 2021
Research Letter
Postoperative Paenibacillus thiaminolyticus Wound Infection, Switzerland
Riccardo Di Micco, Matthias Schneider, and Reto Nüesch
Table
Comparison of MIC and SS of antimicrobial drugs in blood 4 hours after intravenous administration to treat Paenibacillus thiaminolyticus in a patient, Switzerland*
| Antimicrobial drug† | MIC | SSC |
|---|---|---|
| Amoxicillin/clavulanate | 0.064 mg/L | 1.2 mg/L |
| Tetracycline | 12 mg/L | 2.8 mg/L |
| Trimethoprim/sulfamethoxazole‡ | <0.094 mg/L | 1.5–3 mg/L |
| Clindamycin | 0.38 mg/L | 23 mg/L |
| Ciprofloxacin | 0.19 mg/L | 4.56 mg/L |
*No specific clinical breakpoints have been established for Paenibacillus spp. We used European Committee on Antimicrobial Susceptibility Testing pharmacokinetics and pharmacodynamics to determine antimicrobial susceptibility. SSC, steady state concentration.
†Antimicrobial drugs were administered at the recommended doses reported in the manufacturer the data sheets (compendium.ch, https://compendium.ch). ‡Trimethoprim/sulfamethoxazole is dose dependent.
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