SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia
Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K. Taubenberger, Matthew J. Memoli, Kaitlyn Sadtler, Patrick E. Duffy, and Fabiano Oliveira
Author affiliations: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA (J. Manning, I. Zaidi, C. Lon, L.A. Rosas, J.-K. Park, A. Ponce, J. Bohl, J.K. Taubenberger, M.J. Memoli, P.E. Duffy, F. Oliveira); National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia (S. Chea, S. Sreng, H. Rekol, C.M. Chour); National Institute of Biomedical Imaging and Bioengineering, Bethesda (M. Karkanitsa, K. Sadtler); Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA (D. Esposito)
Figure 2. Mean antibody levels in prepandemic serum samples from malaria-positive rural persons in Cambodia, 2005–2011, to A) common cold OC43 and HKU1 viruses, B) Plasmodium falciparum AMA-1 and C) P. falciparum Pfs25 protein by SARS-CoV-2 serosurvey statuses. D–E) Correlation of mean IgG levels of AMA-1 and Pfs25 against Spike (blue triangles), RBD (red circles) and NC (open circles) IgG levels in prepandemic serum samples from malaria-positive rural persons in Cambodia. F) OD levels of RBD protein after preincubation of serum samples with 10mg/mL of AMA-1 or BSA. AMA-1, apical membrane antigen 1; BSA, bovine serum albumin; NC, nucleocapsid; OD, optical density; RBD, receptor binding domain; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
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