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Volume 28, Number 3—March 2022
Research

Higher Viral Stability and Ethanol Resistance of Avian Influenza A(H5N1) Virus on Human Skin

Risa Bandou, Ryohei HiroseComments to Author , Takaaki Nakaya, Hajime Miyazaki, Naoto Watanabe, Takuma Yoshida, Tomo Daidoji, Yoshito Itoh, and Hiroshi Ikegaya
Author affiliation: Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Main Article

Table 1

Survival times and half-lives of various subtypes of influenza viruses on a plastic surface*

Subtype
Median survival time (95% CI), h†
Median half-life (95% CI), h‡
4 (log10 FFU)
3 (log10 FFU)
2 (log10 FFU)
H5N1-Ky 26.35 (23.84–29.01) 1.28 (1.15–1.43) 1.71 (1.54–1.91) 2.56 (2.30–2.86)
H5N1-Eg 26.30 (23.64–29.14) 1.27 (1.13–1.43) 1.69 (1.51–1.90) 2.54 (2.27–2.85)
H7N9 7.97 (6.82–9.27) 0.40 (0.34–0.49) 0.54 (0.45–0.65) 0.81 (0.67–0.98)
H5N3 10.01 (8.35–11.91) 0.52 (0.42–0.65) 0.70 (0.57–0.87) 1.05 (0.85–1.30)
H5N9 8.88 (7.67–10.23) 0.46 (0.39–0.55) 0.61 (0.51–0.73) 0.92 (0.77–1.09)
H3N2 9.28 (7.94–10.79) 0.48 (0.40–0.58) 0.64 (0.54–0.77) 0.96 (0.80–1.16)
H1N1-PR8 9.70 (8.29–11.30) 0.51 (0.42–0.61) 0.68 (0.56–0.82) 1.01 (0.85–1.22)
H1N1-Ok-pdm 8.78 (7.60–10.10) 0.45 (0.38–0.54) 0.60 (0.51–0.72) 0.91 (0.76–1.08)

*FFU, focus-forming units; H5N1-Ky, A/crow/Kyoto/53/04 (H5N1); H5N1-Eg, A/chicken/Egypt/CL6/07 (H5N1); H7N9, A/Anhui/1/23 (H7N9); H5N3, A/Duck/Hong Kong/820/80 (H5N3); H5N9, A/Turkey/Ontario/7732/66 (H5N9); H3N2, Clinical strain (H3N2); H1N1-PR8, A/Puerto Rico /8/1934 (H1N1); H1N1-Ok-pdm, A/Osaka/64/2009 (H1N1). †The elapsed time was used as the explanatory variable (x-axis), and the logarithmic virus titer was used as the explained variable (y-axis). A linear regression analysis with logarithmic link function was performed for each virus to create a curve of regression (Appendix Figure 1). Because the detection limit of each influenza virus titer was 101 FFUs, the X value (when the Y value of the regression curve was 1.0) was used as the survival times. ‡The half-life of each virus was calculated from the slope of each regression curve when the amount of virus remaining on the surface was 2, 3, or 4 log10 FFUs.

Main Article

Page created: January 23, 2022
Page updated: February 21, 2022
Page reviewed: February 21, 2022
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