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Volume 29, Number 10—October 2023
Research

Candida auris Clinical Isolates Associated with Outbreak in Neonatal Unit of Tertiary Academic Hospital, South Africa

Dikeledi Kekana, Serisha D. Naicker, Liliwe Shuping, Sithembiso Velaphi, Firdose L. Nakwa, Jeannette Wadula, Nelesh P. GovenderComments to Author , and for GERMS-SA1
Author affiliations: National Institute for Communicable Diseases, Johannesburg, South Africa (D. Kekana, S.D. Naicker, L. Shuping, N.P. Govender); University of the Witwatersrand, Johannesburg (D. Kekana, S. Velaphi, F.L. Nakwa, J. Wadula, N.P. Govender); Chris Hani Baragwanath Academic Hospital, Johannesburg (S. Velaphi, F.L. Nakwa, J. Wadula); University of Cape Town, Cape Town, South Africa (N.P. Govender); University of Exeter, Exeter, United Kingdom (N.P. Govender)

Main Article

Table 2

MIC distribution of Candida auris isolates (n = 207) from patients admitted to a tertiary academic hospital, South Africa, 2016–2020*

Drug Breakpoint, µg/mL No. isolates with MIC, µg/mL
 Unk† % Resistant
0.008 0.015 0.03 0.06 0.12 0.25 0.5 1 2 4 8 16 32 64 128 256
AFG
≥4
1
28
 129
 42
 7
0
MFG
≥4
2
 96
 94
 12
 1
 2
0
5FC
 ≥128
 3
67
 125
 10
 2
0
POS
NA
 1
 1
 15
 73
 80
 31
 4
 2
NA
VRC
NA
2
 8
 21
 58
 103
 13
 2
NA
ITC
NA
2
 10
 84
 84
 25
 2
NA
FLC
≥32
1
7
 13
 34
 73
 79
96
AMB
≥2
1
 9
 135
 61
1
 42
AMB Etest‡ ≥2 1 1 2 9 22 76 79 11 2 4 6.2

*AMB, amphotericin B; AFG, anidulafungin; FLC, fluconazole; ITC, itraconazole; MFG, micafungin; NA, not available; POS, posaconazole; unk, unknown; VRC, voriconazole; 5FC, flucytosine. †Isolates missing data or not tested ‡MICs were determined using both broth microdilution and E-test method for amphotericin B.

Main Article

1Members of GERMS-SA are listed at the end of this article.

Page created: August 31, 2023
Page updated: September 20, 2023
Page reviewed: September 20, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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