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Volume 29, Number 10—October 2023
Dispatch

Human-to-Human Transmission of Andes Virus Modeled in Syrian Hamsters

Silke A. Riesle-Sbarbaro, Norman Kirchoff, Katharina Hansen-Kant, Alice Stern, Andreas Kurth, and Joseph B. PrescottComments to Author 
Author affiliation: Robert Koch Institute, Berlin, Germany

Main Article

Figure 1

Dissemination and shedding of Andes virus (ANDV) in secretions and excretions of infected Syrian hamsters. A) ANDV RNA small segment loads in oral and rectal mucosa and urine sampled per day postinoculation throughout the experiment. B–C) Total ANDV RNA detected in all shedding routes (oral and rectal mucosa and urine), compared between cohorts (B) and between infected animals of each cohort (C) after adjustment of incubation days (AID). D) Comparison of ANDV RNA load between oral and rectal mucosa samples and urine samples from infected animals, using AID. Individual oral, rectal and urine samples are shown as points. Geometric mean RNA loads are displayed for log10 transformed data in panels B–D; error bars indicate SDs. E) Statistical analysis of survival between cohorts. Significance of Mantel-Cox log-rank test is shown within the plot (p<0.001). F) ANDV RNA distribution shown per gram of tissue or milliliter of blood. As reference, the horizontal grey line shows the inoculum dose. Bla, bladder; Bld, blood; cLN, cervical lymph node; Hrt, heart; Kid, kidney; Liv, liver; Lun, lung; Rec, rectum; SGd, submandibular salivary gland; Spl, spleen; Tra, trachea.

Figure 1. Dissemination and shedding of Andes virus (ANDV) in secretions and excretions of infected Syrian hamsters. A) ANDV RNA small segment loads in oral and rectal mucosa and urine sampled per day postinoculation throughout the experiment. B–C) Total ANDV RNA detected in all shedding routes (oral and rectal mucosa and urine), compared between cohorts (B) and between infected animals of each cohort (C) after adjustment of incubation days (AID). D) Comparison of ANDV RNA load between oral and rectal mucosa samples and urine samples from infected animals, using AID. Individual oral, rectal and urine samples are shown as points. Geometric mean RNA loads are displayed for log10 transformed data in panels B–D; error bars indicate SDs. E) Statistical analysis of survival between cohorts. Significance of Mantel-Cox log-rank test is shown within the plot (p<0.001). F) ANDV RNA distribution shown per gram of tissue or milliliter of blood. As reference, the horizontal grey line shows the inoculum dose. Bla, bladder; Bld, blood; cLN, cervical lymph node; Hrt, heart; Kid, kidney; Liv, liver; Lun, lung; Rec, rectum; SGd, submandibular salivary gland; Spl, spleen; Tra, trachea.

Main Article

Page created: September 15, 2023
Page updated: September 20, 2023
Page reviewed: September 20, 2023
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