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Volume 29, Number 5—May 2023
Research

Use of High-Resolution Geospatial and Genomic Data to Characterize Recent Tuberculosis Transmission, Botswana

Chelsea R. Baker1, Ivan Barilar1, Leonardo S. de Araujo, Anne W. Rimoin, Daniel M. Parker, Rosanna Boyd, James L. Tobias, Patrick K. Moonan, Eleanor S. Click, Alyssa Finlay, John E. Oeltmann, Vladimir N. Minin, Chawangwa Modongo, Nicola M. Zetola2, Stefan Niemann2, and Sanghyuk S. Shin2Comments to Author 
Author affiliations: University of California, Irvine, California, USA (C.R. Baker, D.M. Parker, V.N. Minin, S.S. Shin); Forschungszentrum, Borstel, Germany (I. Barilar, L.S. de Araujo, S. Niemann); University of California, Los Angeles, California, USA (A.W. Rimoin); US Centers for Disease Control and Prevention, Gaborone, Botswana (R. Boyd, A. Finlay); US Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.L. Tobias, P.K. Moonan, R. Boyd, E.S. Click, A. Finlay, J.E. Oeltmann); Botswana–UPenn Partnership, Gaborone (C. Modongo, N.M. Zetola); Victus Global Botswana Organisation, Gaborone (C. Modongo, N.M. Zetola)

Main Article

Figure 2

Kernel density map, median center point, and directional distribution for genotypic groups A–E (≤5 single-nucleotide polymorphisms) (panels A–E) and genotypically ungrouped Mycobacterium tuberculosis strains (F) in study of high-resolution geospatial and genomic data to characterize recent tuberculosis transmission, Gaborone, Botswana, 2012–2016. The blue ovals encompass the area within the SD ellipse, representing the geographic distance and directional orientation of participant locations within each group. Density is shown on a different scale (up to 35 cases/km2) for ungrouped participants than for participants in the genotypic cluster groups (up to 5 cases/km2) because of differences in size of the datasets.

Figure 2. Kernel density map, median center point, and directional distribution for genotypic groups A–E (≤5 single-nucleotide polymorphisms) (panels A–E) and genotypically ungrouped Mycobacterium tuberculosis strains (F) in study of high-resolution geospatial and genomic data to characterize recent tuberculosis transmission, Gaborone, Botswana, 2012–2016. The blue ovals encompass the area within the SD ellipse, representing the geographic distance and directional orientation of participant locations within each group. Density is shown on a different scale (up to 35 cases/km2) for ungrouped participants than for participants in the genotypic cluster groups (up to 5 cases/km2) because of differences in size of the datasets.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: January 18, 2023
Page updated: April 18, 2023
Page reviewed: April 18, 2023
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