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Volume 29, Number 7—July 2023
Research

Systematic Review of Hansen Disease Attributed to Mycobacterium lepromatosis

Simon M. Collin, Amanda Lima, Stéfano Heringer, Vinícius Sanders, Hugo Aborghetti Pessotti, and Patrícia DepsComments to Author 
Author affiliation: Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil

Main Article

Table 2

Specimen surveys investigating Mycobacterium lepromatosis as a cause of Hansen disease*

Ref. Country (origin) Specimen date range Specimens PCR results
 HD types (remarks)
Neg Pos M. lepromatosis Dual infection M. leprae
(3) Mexico Not reported 64 type not reported 0 64 6 0 58 DLL 2
Venezuela Not reported 77 type not reported 0 77 0 0 77
Brazil Not reported 33 type not reported 0 33 0 0 33
Mali Not reported 48 type not reported 0 48 0 0 48
Others
 Not reported
 5 type not reported
 0
 5
 0
 0
 5
(6) Mexico Not reported 47 skin lesion biopsy 11 36 15 2 19
United States 2017 218 type not reported 146 72 3 0 69
Philippines 180 sss 0 180 0 0 180
United States (all but 1 born in Mexico)
 1968–1994
 15 skin biopsy sections
 0
 10
 5
 1
 4
 LL 2, DLL 4 (all originally from Mexico)
(33)
 Colombia†
 2006–2016
 67 skin lesion, 25 earlobe sss
 0
 92
 0
 5
 87
(34)
 Colombia (Cartagena, Bolívar)
 2015–2020
 41 skin biopsy
 7
 41
 0
 0
 34
(35)
 Mexico
 1988–2007
 120 skin biopsy
 33
 87
 55
 14
 18
 B 12, LL 41, DLL 16
(36) Brazil (Curitiba and southern Brazil) 2004–2010 52 skin biopsy 6 46 7 3 36 TT7, LL 3
Myanmar 2007–2008 9 skin biopsy 3 6 2 0 4 LL 2
Malaysia (19), Indonesia (3), Nepal (1), Myanmar (1) 2003–2011 31 skin biopsy 4 27 0 0 27
Uganda
 1979–1990
 4 skin biopsy
 2
 2
 0
 0
 2
(37)
 Mexico
 Current
19 skin biopsy
 9
 10
 2
 1
 7
 LL 2, not determined 1
(38)
 United States (various countries of origin)‡
 2011–2021
 38 tissue
 0
 38
 11
 0
 27
 LL 11 (all originally from Mexico)
(39)
 Mexico§
 1994–2014
 41 skin biopsy
 12
 29
 8
 8
 13
 BL 6, LL 6, DLL 4
(40)
 Mexico
 Current patients
 38 skin biopsy
 0
 38
 5
 0
 33
 BL 1, LL 1, DLL 3
(41)
 China
 Current patients
 171 skin biopsy
 86
 85
 0
 0
 85
(42) China (Shandong province) Not reported 85 skin biopsy 13 72 0 0 72

*B, borderline (BT, BB or BL); BB, mid-borderline (borderline borderline); BL, borderline lepromatous; BT, borderline tuberculoid; DLL, diffuse lepromatous leprosy; ENL, erythema nodosum leprosum (type 2 reaction); LL, lepromatous leprosy; LP, Lucio’s phenomenon (erythema necroticans); neg., negative; pos., positive; ref., reference; sss, skin slit smear; TT, tuberculoid. †Provinces of Atlántico, Antioquia, Bolívar, Chocó, Cesar, Cundinamarca, Magdalena, Santander, Norte de Santander, Sucre, and Tolima. ‡Mexico (22), Philippines (6), Vietnam (1), India (1), Myanmar (1), Marshall Islands (2), El Salvador (2), Brazil (1), United States (2). §Yucatan (16), Guerrero (8), Michoacán (6), Guanajuato (3), Morelos (2), 1 each from Campeche, Ciudad de Mexico, Estado de Mexico, Oaxaca, Puebla, and Quintana Roo.

Main Article

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Page updated: June 20, 2023
Page reviewed: June 20, 2023
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