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Volume 30, Number 2—February 2024
Dispatch

Emerging Enterovirus A71 Subgenogroup B5 Causing Severe Hand, Foot, and Mouth Disease, Vietnam, 2023

Nguyen Van Vinh Chau, Tang Chi Thuong, Nguyen Thanh Hung, Nguyen Thi Thu Hong, Du Tuan Quy, Tran Ba Thien, Cao Minh Hiep, Ngo Ngoc Quang Minh, Truong Huu Khanh, Do Duong Kim Han, Truong Hoang Chau Truc, Nguyen Thi Han Ny, Le Kim Thanh, Lam Anh Nguyet, Cao Thu Thuy, Le Nguyen Truc Nhu, Pham Van Quang, Phung Nguyen The Nguyen, Phan Tu Qui, H. Rogier van Doorn, C. Louise Thwaites, Tran Tan Thanh, Nguyen Thanh Dung, Guy Thwaites, Nguyen To Anh, Le Nguyen Thanh Nhan, Le Van TanComments to Author , and for the SEACOVARIANTS1
Author affiliations: Department of Health, Ho Chi Minh City, Vietnam (N.V.V. Chau, T.C. Thuong); Children’s Hospital 1, Ho Chi Minh City (N.T. Hung, D.T. Quy, C.M. Hiep, N.N.Q. Minh, T.H. Khanh, P.V. Quang, P.N.T. Nguyen, L.N.T. Nhan); Oxford University Clinical Research Unit, Ho Chi Minh City (N.T.T. Hong, T.B. Thien, D.D.K. Han, T.H.C. Truc, N.T.H. Ny, L.K. Thanh, L.A. Nguyet, C.T. Thuy, L.N.T. Nhu, H.R. van Doorn, C.L. Thwaites, T.T. Thanh, G. Thwaites, N.T. Anh, L.V. Tan); Pham Ngoc Thach University of Medicine, Ho Chi Minh City (P.V. Quang); University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City (P.N.T. Nguyen); Hospital for Tropical Diseases, Ho Chi Minh City (P.T. Qui, N.T. Dung); University of Oxford, Oxford, UK (H.R. van Doorn, C.L. Thwaites, G. Thwaites, L.V. Tan)

Main Article

Figure 2

Phylogenetic analysis of viral protein 1 (VP1) coding sequences in study of emerging enterovirus A71 subgenogroup B5 causing severe hand, foot, and mouth disease, Vietnam, 2023. Tree was constructed for VP1 gene sequences by using the maximum-likelihood method to compare genetic relatedness among the B5 sequences from this study and global sequences obtained from GenBank. Line colors indicate the country of origin for each sequence. Box colors indicate the enterovirus lineage. Arrow indicates the emerging B5 lineage from Vietnam carrying an S17G codon substitution within the N-terminus of VP1. Similar phylogenetic tree structure was obtained when the analysis was performed by using complete genome coding sequences. Interlineage and intralineage nucleotide sequence similarities among the lineages were calculated (Appendix Table 3). Scale bar indicates nucleotide substitutions per site.

Figure 2. Phylogenetic analysis of viral protein 1 (VP1) coding sequences in study of emerging enterovirus A71 subgenogroup B5 causing severe hand, foot, and mouth disease, Vietnam, 2023. Tree was constructed for VP1 gene sequences by using the maximum-likelihood method to compare genetic relatedness among the B5 sequences from this study and global sequences obtained from GenBank. Line colors indicate the country of origin for each sequence. Box colors indicate the enterovirus lineage. Arrow indicates the emerging B5 lineage from Vietnam carrying an S17G codon substitution within the N-terminus of VP1. Similar phylogenetic tree structure was obtained when the analysis was performed by using complete genome coding sequences. Interlineage and intralineage nucleotide sequence similarities among the lineages were calculated (Appendix Table 3). Scale bar indicates nucleotide substitutions per site.

Main Article

1Members are listed at the end of this article.

Page created: December 08, 2023
Page updated: January 24, 2024
Page reviewed: January 24, 2024
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