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Volume 30, Number 4—April 2024
Research

A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Jennifer Mattock1Comments to Author , Marie Anne Chattaway, Hassan Hartman, Timothy J. Dallman2, Anthony M. Smith, Karen Keddy, Liljana Petrovska3, Emma J. Manners4, Sanelisiwe T. Duze, Shannon Smouse, Nomsa Tau, Ruth Timme, Dave J. Baker, Alison E. Mather, John Wain, and Gemma C. Langridge
Author affiliations: University of East Anglia, Norwich, UK (J. Mattock, E.J. Manners, A.E. Mather, J. Wain); UK Health Security Agency, London, UK (M.A. Chattaway, H. Hartman, T.J. Dallman); National Institute for Communicable Diseases, Johannesburg, South Africa (A.M. Smith, S. Smouse, N. Tau); University of Pretoria, Pretoria, South Africa (K. Keddy); Animal and Plant Health Agency, Addlestone, UK (L. Petrovska); University of the Witwatersrand, Johannesburg (S.T. Duze); US Food and Drug Administration, College Park, Maryland, USA (R. Timme); Quadram Institute Bioscience, Norwich (D.J. Baker, A.E. Mather, J. Wain, G.C. Langridge)

Main Article

Figure 4

Phylogeny and heatmap of antimicrobial resistance and pESI in study of One Health perspective of emerging multidrug-resistant pathogen Salmonella enterica serovar Infantis. Heatmap shows the number of isolates in each 25 single-nucleotide polymorphism representative cluster (n = 1,288) of the eBG31 maximum-likelihood phylogeny with genes conferring resistance to antimicrobial drugs. Fastbaps clade and the number of isolates with MDR, ESBLs, mutations in the QRDR conferring resistance to fluoroquinolones and pESI presence are also shown. AG, aminoglycosides; BL, β-lactams; CHL, chloramphenicol; COL, colistin; ESBLs, extended β-lactamases; FQ, fluoroquinolones; FOS, fosfomycin; LIN, lincosamides; MAC, macrolides; MDR, multidrug-resistant; SUL, sulphonamides; TET, tetracyclines; TMP, trimethoprim.

Figure 4. Phylogeny and heatmap of antimicrobial resistance and pESI in study of One Health perspective of emerging multidrug-resistant pathogen Salmonella enterica serovar Infantis. Heatmap shows the number of isolates in each 25 single-nucleotide polymorphism representative cluster (n = 1,288) of the eBG31 maximum-likelihood phylogeny with genes conferring resistance to antimicrobial drugs. Fastbaps clade and the number of isolates with MDR, ESBLs, mutations in the QRDR conferring resistance to fluoroquinolones and pESI presence are also shown. AG, aminoglycosides; BL, β-lactams; CHL, chloramphenicol; COL, colistin; ESBLs, extended β-lactamases; FQ, fluoroquinolones; FOS, fosfomycin; LIN, lincosamides; MAC, macrolides; MDR, multidrug-resistant; SUL, sulphonamides; TET, tetracyclines; TMP, trimethoprim.

Main Article

1Current affiliation: University of Edinburgh, Edinburgh, Scotland, UK.

2Current affiliation: Utrecht University, Utrecht, the Netherlands.

3Current affiliation: UK Health Security Agency, London, UK.

4Current affiliation: European Bioinformatics Institute, Cambridge, UK.

Page created: February 08, 2024
Page updated: March 20, 2024
Page reviewed: March 20, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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