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Volume 9, Number 6—June 2003

Histopathologic Features of Mycobacterium ulcerans Infection

Jeannette Guarner*Comments to Author , Jeanine Bartlett*, Ellen A. Spotts Whitney*, Pratima L. Raghunathan*, Ymkje Stienstra†, Kwame Asamoa‡, Samuel Etuaful§, Erasmus Klutse¶, Eric Quarshie#, Tjip S. van der Werf†, Winette T.A. van der Graaf†, C. Harold King**, and David A. Ashford*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Groningen University Hospital, the Netherlands; ‡Ministry of Health, Accra, Ghana; §St. Martins Catholic Hospital, Agroyesum, Ghana; ¶Dunkwa Government Hospital, Dunkwa, Ghana; #Presbyterian Hospital, Agogo, Ghana; **Emory University, Atlanta, Georgia, USA

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Table 3

Comparison of histopathologic features of definite and suspected Buruli ulcer cases

Histopathologic feature Buruli ulcer (AFB positive)a
No. (%) Suspected Buruli ulcer (AFB negative)a no. (%) p value

50/73 (68)
21/35 (60)

45/74 (61)
2/35 (6)
Subcutaneous tissue

78/78 (100)
23/37 (62)
58/78 (74)
27/37 (73)
Acute inflammationc
72/78 (92)
27/37 (73)
Chronic inflammationd
31/78 (40)
18/37 (49)
Granulomase 30/78 (38) 12/37 (32) 0.53

aAFB, acid-fast bacilli.
bSeven specimens did not have epidermis, and six did not have dermis.
cAcute inflammation considered as present versus absent.
dChronic inflammation considered as intense versus mild.
eGranulomas considered as present versus absent.

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Page updated: December 21, 2010
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