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Volume 22, Number 12—December 2016
Research

African Horse Sickness Caused by Genome Reassortment and Reversion to Virulence of Live, Attenuated Vaccine Viruses, South Africa, 2004–2014

Camilla Weyer, John D. Grewar, Phillippa Burger, Esthea Rossouw, Carina Lourens, Christopher Joone, Misha le Grange, Peter Coetzee, Estelle H. Venter, Darren P. Martin, N. James MacLachlan, and Alan J. GuthrieComments to Author 
Author affiliations: University of Pretoria, Onderstepoort, South Africa (C.T. Weyer, P. Burger, C. Lourens, C. Joone, M. le Grange, P. Coetzee, E. Venter, N.J. MacLachlan, A.J. Guthrie); Western Cape Department of Agriculture, Elsenburg, South Africa (J.D. Grewar); Wits Health Consortium, Johannesburg, South Africa (E. Rossouw); University of Cape Town, Cape Town, South Africa (D.P. Martin); University of California, Davis, CA, USA (N.J. MacLachlan)

Main Article

Table 1

Attenuation-associated nonsynonymous SNVs of consensus sequences of genome segments of AHSV-1 viruses from 4 AHS outbreaks in the AHS controlled area of Western Cape Province, South Africa, 2004–2014, and reference strains*

Abbreviated strain name
 Genome segment and amino acid position
 Genotype group
VP2 357
 VP3 232
 VP5 422
 VP5 434
 VP6 81
 VP6 169
 NS3 201
1/E.cab-tc/ZAF/62/OVI-HS29/62 N Y S T A R M
1/Lab/ZAF/98/OBP-116† K H N I V Q K
1/E.cab-tc/ZAF/04/Elb-E040019 ‡ T§ A R E 1a
1/E.cab-tc/ZAF/04/Elb-E040020 T A R E 1a
1/E.cab-tc/ZAF/04/Elb-E040021 T A R E 1a
1/E.cab-tc/ZAF/04/Dkt-E040029 T A R E 1a
1/E.cab-tc/ZAF/04/Tgd-E040031 N T A R 1b
1/E.cab-tc/ZAF/04/Elb-E040034 N T A R 1b
1/E.cab-tc/ZAF/04/Tgd-E040039 N T A R 1b
1/E.cab-tc/ZAF/04/Avt-E040043 N T A R 1b
1/E.cab-tc/ZAF/04/Avt-E040048 N T A R 1b
1/E.cab-tc/ZAF/04/Vdm-E040062 N T A R 1b
1/E.cab-tc/ZAF/04/Tgd-E040064 N T A R 1b
1/E.cab-tc/ZAF/04/Vdm-E040065 N T A 1b
1/E.cab-tc/ZAF/04/Avt-E040066 N T A R 1b
1/E.cab-tc/ZAF/04/Avt-E040081 N T A R 1b
1/E.cab-tc/ZAF/04/Kbk-E040086 N T A R 1b
1/E.cab-tc/ZAF/04/Avt-E040061 N A R 1c
1/E.cab-tc/ZAF/11/Mre-E110143_1 T A R N 2
1/E.cab-tc/ZAF/11/Mre-E110180_WC44 T A R N 2
1/E.cab-tc/ZAF/11/Mre-E110180_WC61 T A R N 2
1/E.cab-tc/ZAF/11/Mre-E110180_WC165 T A R N 2
1/E.cab-tc/ZAF/11/Mre-E110411_1 T A R N 2
1/E.cab-tc/ZAF/11/Mre-E110418_1 T A R N 2
1/E.cab-tc/ZAF/11/Mre-E110674_3 T A R N 2
1/E.cab-tc/ZAF/14/Ptv-E140485_WC00522 T A R 3a
1/E.cab-tc/ZAF/14/Ptv-E140485_WC00528 T A R 3a
1/E.cab-tc/ZAF/14/Ptv-E140485_WC00533 T A R 3a
1/E.cab-tc/ZAF/14/Ptv-E140485_WC00544 T A R 3a
1/E.cab-tc/ZAF/14/Ptv-E140485_WC00555 T A R 3a
1/E.cab-tc/ZAF/14/Srn-E140526_WC00481 T A R 3a
1/E.cab-tc/ZAF/14/Srn-E140526_WC00482 T A R 3a
1/E.cab-tc/ZAF/14/Srn-E140526_WC00488 T A R 3a
1/E.cab-tc/ZAF/14/Srn-E140526_WC00491 T A R 3a
1/E.cab-tc/ZAF/14/Srn-E140526_WC00493 T A R 3a
1/E.cab-tc/ZAF/14/Srn-E140526_WC00502 T A R 3a
1/E.cab-tc/ZAF/14/Ptv-E140536_WC00506 T A R 3a
1/E.cab-tc/ZAF/14/Ptv-E140536_WC00507 T A R 3a
1/E.cab-tc/ZAF/14/Ptv-E140536_WC00508 T A R 3a
1/E.cab-tc/ZAF/14/Rbn-E140702_RB00008 T A R 3b
1/E.cab-tc/ZAF/14/Rbn-E140816_RB00221 T A R 3b

*AHS, African horse sickness; AHSV-1, AHS virus type 1; NS3, nonstructural protein 3; SNV, single-nucleotide variants; VP, viral protein.
†The changes in amino acids are indicated in comparison with the AHSV-1 live, attenuated vaccine-derived strain (1/Lab/ZAF/98/OBP-116) for relevant viral proteins.
‡Sequences that were identical to the consensus sequence of the vaccine-derived strain are indicated by an empty cell.
§Sequences that differed from the consensus sequence of the AHSV-1 live, attenuated vaccine-derived strain are indicated with the letter symbol of the relevant amino acid.
¶Indicates that these segments were not considered due to a recombination event that occurred with another vaccine-derived AHSV type.

Main Article

Page created: November 17, 2016
Page updated: November 17, 2016
Page reviewed: November 17, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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