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Volume 22, Number 2—February 2016

Randomized Controlled Trial of Hospital-Based Hygiene and Water Treatment Intervention (CHoBI7) to Reduce Cholera

Christine Marie GeorgeComments to Author , Shirajum Monira, David A. Sack, Mahamud-ur Rashid, K.M. Saif-Ur-Rahman, Toslim Mahmud, Zillur Rahman, Munshi Mustafiz, Sazzadul Islam Bhuyian, Peter J. Winch, Elli Leontsini, Jamie Perin, Farzana Begum, Fatema Zohura, Shwapon Biswas, Tahmina Parvin, Xiaotong Zhang, Danielle Jung, R. Bradley Sack, and Munirul Alam
Author affiliations: Johns Hopkins University, Baltimore, Maryland, USA (C.M. George, D.A. Sack, P.J. Winch, E. Leontsini, J. Perin, X. Zhang, D. Jung, R.B. Sack); icddr,b, Dhaka, Bangladesh (S. Monira, M. Rashid, K.M. Saif-Ur-Rahman, T. Mahmud, Z. Rahman, M. Mustafiz, S.I. Bhuyian, F. Begum, F. Zohura, S. Biswas, T. Parvin, M. Alam)

Main Article

Table 3

Odds ratios for hand washing with soap and water treatment and indicators of water quality in an intervention study of Vibrio cholerae, Dhaka, Bangladesh, June 2013–November 2014

Outcome No. complying/no. persons (%)
Odds ratio* (95% CI) p value*
Control arm Intervention arm
Hand washing with soap events at key times during 5-h structured observation 50/629 (8) 418/759 (55) 14.68 (8.32–25.90) <0.0001
Hand washing with soap events after toileting during 5-h structured observation 23/123 (19) 144/197 (73) 12.14 (5.68–25.93) <0.0001
Household visits with soap in latrine area, visits 2–5† 50/332 (15) 326/327 (99.7) 1,842.36 (241.53–145,054.53) <0.0001
Household visits with soap in kitchen area, visits 2–5† 43/332 (13) 317/327 (97) 213.64 (62.59–729.24) <0.0001
Households visits with detectable free chlorine >0.2 mg/L in household stored drinking water, visits 2–5‡ 1/332 (<1) 308/327 (94) 4,878.62 (799.30–4.503 × 1015) <0.0001
Household visit with stored water with detectable V. cholerae, visits 2–5 5/83 (6) 0/82 (0) 0.00 (0–1.08)§ 0.06¶
Household visit with source water with detectable V. cholerae, visits 2–5 15/83 (18) 22/82 (27) 1.66 (0.79–3.49) 0.18

*Logistic regression using generalized estimating equations.
†Soap present within 10 steps of the latrine or cooking area at household visits during the intervention period.
‡Cutoff recommended by the Centers for Disease Control and Prevention (Atlanta, GA, USA).
§To calculate exact 95% CIs, an algorithm was used to invert test statistics.
¶Fisher exact test.

Main Article

Page created: January 13, 2016
Page updated: January 13, 2016
Page reviewed: January 13, 2016
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