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Volume 24, Number 1—January 2018

Emergence of Vaccine-Derived Polioviruses during Ebola Virus Disease Outbreak, Guinea, 2014–2015

Maria Dolores Fernandez-GarciaComments to Author , Manasi Majumdar, Ousmane Kebe, Aichatou D. Fall, Moussa Kone, Mouctar Kande, Moustapha Dabo, Mohamed Salif Sylla, Djenou Sompare, Wayne Howard, Ousmane Faye, Javier Martin1, and Kader Ndiaye1
Author affiliations: Institut Pasteur, Dakar, Senegal (M.D. Fernandez-Garcia, O. Kebe, A.D. Fall, O. Faye, K. Ndiaye); National Institute for Biological Standards and Control, Potters Bar, UK (M. Majumdar, J. Martin); World Health Organization, Conakry, Guinea (M. Kone, M. Kande); Guinean Ministry of Health, Conakry (M. Dabo, M.S. Sylla, D. Sompare); National Institute for Communicable Diseases, Johannesburg, South Africa (W. Howard)

Main Article

Table 6

Estimates of average evolutionary divergence over type-2 vaccine-derived poliovirus sequence pairs and the Sabin-2 oral poliovirus strain*

Location nt p-distance value SE aa p-distance value SE
Within lineage 1 0.017 ± 0.003 0.009 ± 0.004
Within lineage II 0.002 ± 0.001 0.003 ± 0.002
Between lineages I and II 0.028 ± 0.004 0.013 ± 0.005
Between lineage I – Sabin 2 0.025 ± 0.005 0.021 ± 0.007
Between lineage II – Sabin 2 0.024 ± 0.005 0.015 ± 0.006

*No. base substitutions/site or amino acid (aa) differences from averaging over all sequence pairs within or between each lineage are shown. Analyses were conducted by using the Kimura 2-parameter model and the pairwise distance at the nucleotide (nt) and aa levels, respectively. All positions containing gaps and missing data were eliminated. SES were obtained by a bootstrap procedure (1,000 replicates).

Main Article

1These authors contributed equally to this article.

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