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Volume 26, Number 3—March 2020
Synopsis

Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan1

Yassir A. ShuaibComments to Author , Eltahir A.G. Khalil, Lothar H. Wieler, Ulrich E. Schaible, Mohammed A. Bakheit, Saad E. Mohamed-Noor, Mohamed A. Abdalla, Glennah Kerubo, Sönke Andres, Doris Hillemann, Elvira Richter, Katharina Kranzer, Stefan Niemann2, and Matthias Merker2Comments to Author 
Author affiliations: Freie Universität Berlin, Berlin, Germany (Y.A. Shuaib, L.H. Wieler); Research Center Borstel, Borstel, Germany (Y.A. Shuaib, U.E. Schaible, S. Andres, D. Hillemann, S. Niemann, M. Merker); Sudan University of Science and Technology, Khartoum, Sudan (Y.A. Shuaib, S.E. Mohamed-Noor, M.A. Abdalla); University of Khartoum, Khartoum, Sudan (E.A.G. Khalil, M.A. Bakheit); Robert Koch Institute, Berlin (L.H. Wieler); Kenyatta University, Nairobi, Kenya (G. Kerubo); Labor Limbach, Heidelberg, Germany (E. Richter); London School of Hygiene and Tropical Medicine, London, UK (K. Kranzer); German Center for Infection Research, Borstel Site, Borstel (S. Niemann, M. Merker)

Main Article

Table 3

Mutations conferring drug resistance among Mycobacterium tuberculosis complex genotypes identified in eastern Sudan, 2014 and 2016*

Genotype
 No. (%) strains
 No. (%) strains with mutations for drug
 No. (%) mutations/genotype
 No. (%) strains/genotype
SM
 INH
 RIF
 EMB
 PZA
 Non-MDR
MDR
Delhi/CAS 122 (73.5) 28 (85.0) 17 (100) 17 (100) 12 (100) 1 (100) 75 (93.75) 16 (76.1) 15 (100)
EAI 4 (2.4) 0 0 0 0 0 0 0 0
LAM 5 (3.0) 0 0 0 0 0 0 0 0
Uganda 4 (2.4) 1 (3.0) 0 0 0 0 1 (1.25) 1 (4.8) 0
S-type 2 (1.2) 0 0 0 0 0 0 0 0
Haarlem 5 (3.0) 0 0 0 0 0 0 0 0
Sudan H37Rv-like 4 (2.4) 0 0 0 0 0 0 0 0
X-type 2 (1.2) 1 (3.0) 0 0 0 0 1 (1.25) 1 (4.8) 0
Cameroon 2 (1.2) 0 0 0 0 0 0 0 0
Euro-American 15 (9.0) 2 (6.0) 0 0 0 0 2 (2.5) 2 (9.5) 0
Beijing 1 (0.6) 1 (3.0) 0 0 0 0 1 (1.25) 1 (4.8) 0
Total 166 (100) 33 (100) 17 (100) 17 (100) 12 (100) 1 (100) 80 (100) 21 (100) 15 (100)

*CAS, Central Asian strain; EAI, East African Indian; EMB, ethambutol; INH, isoniazid; LAM, Latin American Mediterranean; MDR, multidrug-resistant; PZA, pyrazinamide; RIF, rifampin; SM, streptomycin.

Main Article

1Preliminary results from this study were presented at the 39th Annual Congress of the European Society of Mycobacteriology, July 1–4, 2018, Dresden, Germany.

2These authors contributed equally to this article.

Page created: February 20, 2020
Page updated: February 20, 2020
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