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Volume 26, Number 4—April 2020

Genomic Insight into the Spread of Meropenem-Resistant Streptococcus pneumoniae Spain23F-ST81, Taiwan

Yi-Yin Chen1, Yu-Chia Hsieh1Comments to Author , Yu-Nong Gong, Wei-Chao Liao, Shiao-Wen Li, Ian Yi-Feng Chang, Tzu-Lung Lin, Ching-Tai Huang, Cheng-Hsiu Chiu, Tsu-Lan Wu, Lin-Hui Su, Ting-Hsuan Li, and Ya-Yu Huang
Author affiliations: Chang Gung Children’s Hospital, Taoyuan, Taiwan (Y.-Y. Chen, Y.-C. Hsieh, C.-H. Chiu, T.-H. Li, Y.-Y. Huang); Chang Gung University, Taoyuan (Y.-N. Gong, W.-C. Liao, S.-W. Li, I.Y.-F. Chang, T.-L. Lin, T.-L. Wu, L.-H. Su); Linkou Chang Gung Memorial Hospital, Taoyuan (Y.-N. Gong, W.-C. Liao, C.-T. Huang, T.-L. Wu, L.-H. Su)

Main Article

Table 2

Pneumococcal transformation study results for study of invasive Streptococcus pneumoniae isolates from 2 tertiary hospitals in Taiwan, 2013–2017*

Recipient Transforming DNA Transformant name Colony formation MIC of transformants, mg/L
Integration of altered 
PBP in transformants PBP profile
Meropenem Penicillin
R6 NA R6-WT ND 0.015 0.015 ND 2:0:2
15A-ST63 NA 15A-WT ND 1 4 ND 13:new1:43
R6 pbp1a R6–1A ND ND ND ND
R6 pbp2b R6–2B + 0.06 0.015 Yes, PBP2b 2:new1:2
R6 pbp2x R6–2X ND ND ND ND
R6–2B transformants pbp2x R6–2B-2X + 0.25 0.125 Yes, PBP2x 2:new1:43
R6–2B transformants pbp1a R6–2B-1A ND ND ND ND
R6–2B-2X transformants pbp1a R6–2B-2X-1A + 0.5 1 Yes, PBP1a 13:new1:43

*NA, not applicable; ND, not done; PBP, penicillin binding protein; +, positive for colony formation on antimicrobial-containing agar plate; −, negative for colony formation on antimicrobial-containing agar plate.

Main Article

1These first authors contributed equally to this article.

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