Volume 27, Number 1—January 2021
Research
Post–13-Valent Pneumococcal Conjugate Vaccine Dynamics in Young Children of Serotypes Included in Candidate Extended-Spectrum Conjugate Vaccines
Shalom Ben-Shimol, Noga Givon-Lavi, Leore Kotler, Bart Adriaan van der Beek, David Greenberg, and Ron Dagan
Table 2
Proportions of VT20–13/NVT20 ratios in children age <24 mo, Israel, 2009–2011 and 2015–2017*
| Clinical characteristic | 2009–2011 |
2015–2017 |
2015–2017 vs. 2009–2011 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| VT20–13, % | NVT20, % | VT20–13/NVT20 ratio (95% CI) | VT20–13, % | NVT20, % | VT20–13/NVT20 ratio (95% CI) | VT20–13/NVT20 ratio (95% CI) | |||
| Carriage in healthy children | NA | NA | NA | 24 | 66 | 0.37 (0.33–0.41) | NA | ||
| Carriage in non-LRTI | 18 | 38 | 0.46 (0.38–0.56) | 23 | 66 | 0.35 (0.30–0.40) | 0.80 (0.65–0.98) | ||
| Conjunctivitis | 20 | 34 | 0.60 (0.39–0.91) | 19 | 72 | 0.26 (0.17–0.40) | 0.57 (0.35–0.94) | ||
| Carriage in LRTI | 13 | 34 | 0.39 (0.30–0.50) | 32 | 57 | 0.56 (0.48–0.65) | 1.26 (1.00–1.60) | ||
| OM | 14 | 21 | 0.68 (0.49–0.94) | 34 | 52 | 0.60 (0.44–0.81) | 0.91 (0.66–1.25) | ||
| IPD | 15 | 13 | 1.19 (0.79–1.80) | 52 | 38 | 1.40 (1.12–1.73) | 1.05 (0.84–1.31) | ||
*No data were available for healthy children in 2009–2011. IPD, invasive pneumococcal disease; LRTI, lower respiratory tract infection; NA, not applicable; NVT20, serotypes not included in PCV20; OM, otitis media; PCV, pneumococcal conjugate vaccine; VT20–13, additional 20-valent PCV (PCV20) serotypes, not included in PCV13.
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